Results 11 to 20 of about 225,175 (395)

Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease

open access: yesCells, 2021
The microbial metabolite butyrate serves as a link between the intestinal microbiome and epithelium. The monocarboxylate transporters MCT1 and SMCT1 are the predominant means of butyrate transport from the intestinal lumen to epithelial cytoplasm, where ...
Pilyung Stephen Oh, Robert A Cowles
exaly   +4 more sources

Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

open access: yesFrontiers in Microbiology, 2023
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate).
Vineet Singh, Tatsuya Unno, Hong Koh
exaly   +4 more sources

Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression

open access: yesRedox Biology, 2023
Ferroptosis has emerged to be a promising approach in cancer therapies; however, colorectal cancer (CRC) is relatively insensitive to ferroptosis. Exactly how the gut microenvironment impacts the ferroptotic sensitivity of CRC remains unknown. Herein, by
Ying He   +15 more
doaj   +2 more sources

Isolation and characterization of Faecalibacterium prausnitzii from calves and piglets. [PDF]

open access: yes, 2014
The goal of our study was to isolate and characterize Faecalibacterium prausnitzii from fecal samples of healthy calves and piglets, in order to develop a novel probiotic for livestock animals.
Bicalho, Rodrigo C   +6 more
core   +13 more sources

Butyrate Properties in Immune-Related Diseases: Friend or Foe?

open access: yesFermentation, 2023
Butyrate is a short-chain fatty acid (SCFA) created within the intestinal lumen by bacterial fermentation of largely undigested dietary carbohydrates.
Muhammad Anshory   +7 more
doaj   +1 more source

Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells

open access: yesGut, 2023
Objective Roseburia intestinalis is a probiotic species that can suppress intestinal inflammation by producing metabolites. We aimed to study the role of R. intestinalis in colorectal tumourigenesis and immunotherapy. Design R. intestinalis abundance was
X. Kang   +9 more
semanticscholar   +1 more source

Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease.

open access: yesClinical Nutrition, 2022
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also signals through three G-protein coupled receptors. It is clear that butyrate
K. Hodgkinson   +7 more
semanticscholar   +1 more source

Encapsulation of butyrate using low-alkali konjac gel induced by ethanol for colonic delivery

open access: yesFood Hydrocolloids for Health, 2021
Butyrate administrated in proper concentration is beneficial to the human colon environment. However, the delivery of butyrate to the colon is quite difficult as butyrate could be easily absorbed in the upper gastrointestinal tract.
Yousong Ma   +3 more
doaj   +1 more source

Polyvinyl Butyrate Nanoparticles as Butyrate Donors for Colitis Treatment

open access: yesACS Applied Bio Materials, 2021
Butyrate has been attracting attention for the suppression of inflammatory bowel disease (IBD). However, clinical trials of butyrate for IBD treatment have resulted in controversial outcomes, likely owing to the adverse effect of butyrate on the intestinal epithelium that was observed at high butyrate concentrations.
Yunmei Mu   +9 more
openaire   +3 more sources

Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review

open access: yesNutrients, 2023
Background and objective: Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic inflammatory disorder characterized by aberrant immune responses and compromised barrier function in the gastrointestinal tract ...
Neeraja Recharla   +2 more
semanticscholar   +1 more source

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