Results 41 to 50 of about 121,706 (306)

Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes

, 2022
Skeletal muscle insulin resistance is a key pathophysiological process that precedes the development of type 2 diabetes. Whereas an overload of long-chain fatty acids can induce muscle insulin resistance, butyrate, a short -chain fatty acid (SCFA ...
Homan, E., Langelaar-Makkinje, Miriam, Gerding, A., Vieira-Lara, M.A., Huijkman, N., Vieira-Lara, Marcel A., Reijngoud, D.J., Rensen, Patrick C. N., Reijngoud, Dirk-Jan, Bakker, B.M., Bakker, Barbara M., Wolters, Justina C; id_orcid, Rios-Morales, M., Langelaar-Makkinje, M., Li, Z., Wolters, Justina C., Rensen, P.C.N., Vieira-Lara, Marcel A; id_orcid, Reijngoud, Dirk-Jan; id_orcid, Bakker, Barbara M; id_orcid, Rios-Morales, Melany, Homan, Esther; id_orcid, Wolters, J.C., Gerding, Albert, Homan, Esther, Langelaar-Makkinje, Miriam; id_orcid, Li, Zhuang, Huijkman, Nicolette, Rensen, Patrick C N   +28 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Gut Microbes, 2022
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood.
Morgane Modoux, Nathalie Rolhion, Jeremie H. Lefevre, Cyriane Oeuvray, Petr Nádvorník, Peter Illes, Patrick Emond, Yann Parc, Sridhar Mani, Zdenek Dvorak, Harry Sokol   +10 more
doaj   +1 more source

A common mechanism links activities of butyrate in the colon

, 2017
Two biological activities of butyrate in the colon (suppression of proliferation of colonic epithelial stem cells and inflammation) correlate with inhibition of histone deacetylases.
Michael J., Fink, Mohit, S. Verma, Stacy S., Ryu, George M., Whitesides, Hera, Vlamakis, Ramnik J., Xavier, Takahiro E., Ohara, Gabriel L, Salmon, Nadine, Fornelos, Thaddeus, S. Stappenbeck   +9 more
core   +1 more source

Microbiota changes after butyrate.

, 2022
P values for the changes in fecal microbiota between the baseline and the end of the 3-week follow-up (time3). Data are shown for the group with the standard salt substitution (treatment_standard; 0 weeks vs 3 weeks), and for the group attending the ...
Aki Saarikivi (12850879), Anne Salonen (188374), Miikka Höyhtyä (12850900), Katri Korpela (531650), Markku Lehto (135047), Jani Mälkönen (12850882), Krishna Adeshara (12850888), Sohvi Hörkkö (173088), Anu Haaramo (12850903), Kaija-Leena Kolho (6168578), Satu Wedenoja (12850876), Saara Leskinen (12850885), Laura Merras-Salmio (12850897), Jetta Tuokkola (12850891), Anne Nikkonen (12850894), Willem M. de Vos (7628168)   +15 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Evidence for proton-pump inhibitor (PPI)-associated dysbiosis in metabolically unhealthy obesity

Frontiers in Endocrinology, 2023
Obesity adversely impacts millions of American adults by predisposing them to significant health risks and further complications. Obesity is differentiated into two groups: metabolically healthy and metabolically unhealthy.
Melissa A. Burmeister, Tara E. Smith, Timothy K. Fincher, Abby J. Weldon   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Sodium Butyrate Ameliorates Gut Microbiota Dysbiosis in Lupus-Like Mice

Frontiers in Nutrition, 2020
Gut microbiota has a strong influence on the onset and development of systemic lupus erythematosus (SLE), and several studies have demonstrated the effectiveness of microbiota-derived butyrate to ameliorate SLE.
Hanchang He, Hanchang He, Haoming Xu, Jing Xu, Hailan Zhao, Qianyun Lin, Youlian Zhou, Yuqiang Nie   +7 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source