Journal of Translational Medicine, 2023 Background Diabetic retinopathy (DR) development is associated with disturbances in the gut microbiota and related metabolites. Butyric acid is one of the short-chain fatty acids (SCFAs), which has been found to possess a potential antidiabetic effect ...
Yinhua Huang +11 more
semanticscholar +1 more source
Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study [PDF]
, 2016 The short-chain fatty acids (SCFAs), acetate, propionate and butyrate, are bacterial metabolites that mediate the interaction between the diet, the microbiota and the host.
Annaert, Pieter +12 more
core +1 more source
Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
Redox Biology, 2017 Butyrate is one of the short chain fatty acids, produced by the gut microbiota during anaerobic fermentation of dietary fibres. It has been shown that it can inhibit tumor progression via suppressing histone deacetylase and can induce apoptosis in cancer
Kishor Pant +5 more
doaj +1 more source
Experiments and simulations on short chain fatty acid production in a colonic bacterial community [PDF]
, 2018 Understanding how production of specific metabolites by gut microbes is modulated by interactions with surrounding species and by environmental nutrient availability is an important open challenge in microbiome research.
Bobrow, Johanna +6 more
core +1 more source
Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]
, 2018 Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S. +3 more
core +1 more source
Nature Communications, 2022 The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show decreased diversity in the gut microbiota of AML patients or murine models.
Ruiqing Wang +8 more
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2021 Short chain fatty acids readily crosses the gut-blood and blood–brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system ...
Toshikatsu Okumura +5 more
doaj +1 more source
Electron bifurcation mechanism and homoacetogenesis explain products yields in mixed culture anaerobic fermentations [PDF]
, 2017 Anaerobic fermentation of organic wastes using microbial mixed cultures is a promising avenue to treat residues and obtain added-value products. However, the process has some important limitations that prevented so far any industrial application.
González-Cabaleiro, R. +4 more
core +4 more sources
Transcriptome characterization by RNA-seq unravels the mechanisms of butyrate-induced epigenomic regulation in bovine cells. [PDF]
PLoS ONE, 2012 Short-chain fatty acids (SCFAs), especially butyrate, affect cell differentiation, proliferation, and motility. Butyrate also induces cell cycle arrest and apoptosis through its inhibition of histone deacetylases (HDACs).
Sitao Wu +3 more
doaj +1 more source
The Role of Gut Microbiome-Derived Short Chain Fatty Acid Butyrate in Hepatobiliary Diseases.
American Journal of Pathology, 2023 The multiple beneficial effects of the short-chain fatty acid (SCFA) butyrate on human health, produced from fermentable carbohydrates by gut microbiota in the colon, are well known.
Kishor Pant +3 more
semanticscholar +1 more source