Results 191 to 200 of about 303,050 (262)

The MHV-68 nuclear egress complex supports C-capsid selective capsid egress. [PDF]

J Virol
Sanders S, Schneider C, Soh TK, Kotova E, Stalling D, Steer B, Reimer R, Ruzsics Z, Adler H, Bosse JB.   +9 more
europepmc   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Chemically Fueled Systems Chemistry Across Length Scales

Advanced Functional Materials, EarlyView.
Chemically fueled reaction cycles regulate processes through single and multiple catalytic sites on the molecular and assembly scale. This gives rise to unique kinetically controlled properties/functions like spatio‐temporal catalysis, oscillations, optical properties, and perform work.
Brigitte A. K. Kriebisch, Job Boekhoven
wiley   +1 more source

A <i>de novo</i> heterozygous <i>PSTPIP1</i> variant associated with PAPA syndrome: a Chinese case report and literature review. [PDF]

Front Genet
Wang M, Zhang P, Shen M.
europepmc   +1 more source

Mechanically Mutable Matrices: A Hierarchical Investigation of Decellularized Sea Cucumber Collagen as an Adaptable Scaffold Material

Advanced Functional Materials, EarlyView.
Sea cucumber mutable collagenous tissue (MCT) is a remarkable collagen‐based material which can rapidly undergo large changes in stiffness through transiently bound effector proteins. Here, we investigate the hierarchical structure and mechanical response of MCT from Cucumaria frondosa across length scales with a wide range of methods, also exploring ...
Nathalie R. H. Singh, Amy K. Lin, Sabra Rostami, Cameron Hastie, Paul W. Wiseman, Patrick Flammang, Christopher Moraes, Matthew J. Harrington   +7 more
wiley   +1 more source

Optimizing Pediatric Drug Therapy: Pediatric Pharmacokinetics and Administration Routes. [PDF]

J Pediatr Pharmacol Ther
Ngcobo NN.
europepmc   +1 more source

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

Advanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik, Prannoy Seth, Maximilian Fusenig, Jens Friedrichs, Nicole Fertala, Passant Atallah, Uwe Freudenberg, Ayala Lampel, Carsten Werner   +8 more
wiley   +1 more source

Membrane protein structure and dynamics probed by MicroED. [PDF]

Biochem Soc Trans
Paz O, Gonen T.
europepmc   +1 more source

Coordinated Architectural and Chemical Reinforcement in the Crushing Mandible of a Soldier Termite

Advanced Functional Materials, EarlyView.
The crushing mandible of a soldier termite withstands substantial biting loads despite lacking mineral. Its cuticle is partitioned: convex teeth pair hardness and zinc enrichment with aligned chitin fibers for contact durability, while stiffer concave regions between teeth carry bending loads.
Andrew Tran Nguyen, Patryk Wąsik, Juan Fernando Cucuyame Morales, Marie Kate Palau, Adrian Francisco Duran Ornelas, Phani Saketh Dasika, Jin Hee Kim, Radhika Laxminarayana, Eric Hintsala, Greta Chang, Junzhi Liao, Lizhi Sun, Nathan Lord, Atsushi Arakaki, Paul Bardunias, Pablo Zavattieri, David Kisailus   +16 more
wiley   +1 more source

Population-scale repeat expansions elucidate disease risk and brain atrophy. [PDF]

Nature
Pounraja VK, Sul JH, Herman J, O'Keeffe S, Rajagopal V, Bai X, Kessler MD, Parikshak N, Landheer K, Zhang X, Yu S, Zhang L, LeBlanc MG, Rico-Varela J, Grau F, Wolf S, Sundaramoorthy S, Sepehrband F, Stahl EA, Huo Y, Ahmed M, Croll S, GHS-RGC DiscovEHR Collaboration, Mayo-RGC Project Generation, Penn Medicine BioBank, Salerno W, Overton JD, Marchini J, Reid J, Lotta LA, Baras A, Regeneron Genetics Center, Abecasis GR, Coppola G, Gelfman S.   +34 more
europepmc   +1 more source