Results 241 to 250 of about 205,619 (384)

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2‐Positive Cancers

Cancer Science, EarlyView.
Overexpression of ABC transporters, especially ABCG2 and ABCB1, mediates acquired resistance to T‐DXd in HER2‐positive cancers. Inhibition of these transporters restored T‐DXd efficacy, highlighting efflux‐mediated resistance as a potential therapeutic target. ABSTRACT Antibody–drug conjugates (ADCs) are emerging as a promising class of targeted cancer
Yuya Murase, Shigeki Nanjo, Sachiko Arai, Sota Kondo, Hayato Koba, Yifeng Liu, Koji Fukuda, Shigeki Sato, Jun Kinoshita, Noriyuki Inaki, Tsukasa Ueda, Shunichi Nomura, Yuichi Tambo, Takahiro Shimizu, Masafumi Horie, Daichi Maeda, Richard W. Wong, Kazuyoshi Hosomichi, Takafumi Kobayashi, Satoshi Watanabe, Kenta Yamamura, Noriyuki Ohkura, Miki Abo, Seiji Yano   +23 more
wiley   +1 more source

Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx. [PDF]

World J Stem Cells
Klabukov ID, Kisel A, Yatsenko E, Sulina Y, Baranovskii DS.   +4 more
europepmc   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

Ralstonia pickettii—innocent bystander or a potential threat? [PDF]

, 2006
Ingrid Stelzmueller, M. Biebl, Silke Wiesmayr, M. Eller, Elisabeth Hoeller, Manfred Fille, Günter Weiß, Cornelia Lass‐Flörl, Hugo Bonatti   +8 more
openalex   +1 more source

Epidemiology and outcomes of out-of-hospital cardiac arrests at sport and recreational events in England, 2015-2022. [PDF]

Resusc Plus
Winterburn H, Perkins GD, Ji C, Booth S, de Paeztron A, Fothergill R, Brown TP.   +6 more
europepmc   +1 more source

Early Detection of Lower Adherence to Long‐Term e‐Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis?

Clinical &Experimental Allergy, EarlyView.
Adherence to e‐Diary reporting was investigated in a blended care setting among pollen allergic patients with heterogeneous cultural backgrounds. A stable ‘higher’ and a more variable ‘lower’ adherence cluster were identified. Early identification of lower adherence is possible and might inform early interventions to improve patient adherence. ABSTRACT
S. Dramburg, C. J. Hernandez Toro, U. Grittner, S. Tripodi, S. Arasi, A. Acar Şahin, X. Aggelidis, A. Barbalace, A. Bourgoin, B. Bregu, M. A. Brighetti, E. Caeiro, S. Caglayan Sozmen, L. Caminiti, D. Charpin, M. Couto, L. Delgado, A. Di Rienzo Businco, C. Dimier, M. V. Dimou, J. A. Fonseca, O. Goksel, D. Hernandez, T. M. Hoffmann, D. T. Jang, F. Kalpaklioglu, B. Lame, R. Llusar, M. Makris, A. Mazon, E. Mesonjesi, A. Nieto, A. Öztürk, L. Pahus, G. Pajno, I. Panasiti, N. G. Papadopoulos, E. Pellegrini, S. Pelosi, A. M. Pereira, M. Pereira, N. M. Pinar, E. Potapova, A. Priftanji, F. Psarros, C. Sackesen, I. Sfika, J. Suarez, M. Thibaudon, A. Travaglini, U. Uguz, V. Verdier, V. Villella, P. Xepapadaki, D. Yazici, P. M. Matricardi   +55 more
wiley   +1 more source

Bullies, victims, bystanders: How do they react during anti-bullying sessions?

, 1999
Lucia Berdondini
openalex   +1 more source

Cardiac Arrest Care on United States Golf Courses-Up to Par Yet? [PDF]

J Am Coll Emerg Physicians Open
Gustafson B, Todd B, Prescott P, Xing Y, McNally B, Qi M, Al-Araji R, Swor R, CARES Surveillance Group.   +8 more
europepmc   +1 more source

The Role of Children's Voices and Feedback Mechanisms in Family Justice

Child &Family Social Work, EarlyView.
ABSTRACT When parents separate in Australia and in many other jurisdictions, most settle the parenting arrangements for their children between themselves or with the assistance of mediation or other dispute resolution processes. These processes may or may not take much account of children's views.
Judith Cashmore
wiley   +1 more source

Differential response to right ventricular extrastimuli from the base and apex during long RP′ supraventricular tachycardia

Journal of Arrhythmia
Hironori Nakamura, Hidehira Fukaya, Naruya Ishizue, Jun Kishihara, Junya Ako   +4 more
doaj   +1 more source