Results 121 to 130 of about 117,695 (339)

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, EarlyView.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Cyber victimization experience, uncertainty stress, and internet self-efficacy as predictors of negative bystander behavior in cyberbullying among adolescents: a moderated mediation model

BMC Psychology
Background Negative bystander behaviors significantly impact the trajectory of cyberbullying incidents. Previous research has established a link between cyber victimization experience and negative bystander behavior in cyberbullying.
Rui Chen, Dan Ming, Xin Hao, Zhen Hu, Min Zhao, Cuiying Fan   +5 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Prevalence of transthyretin cardiac amyloidosis in undifferentiated heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1176-1182, April 2025.
Abstract Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an increasinglyrecognized cause of heart failure with preserved ejection fraction (HFpEF), which may be diagnosed non‐invasively using 99mTc 3,3‐diphosphono‐1,2‐propanodicarboxylic acid (DPD) scintigraphy‐based diagnostic criteria.
L. Healy, G. Giblin, A. Gray, N. Starr, L. Murphy, D. O'Sullivan, E. Kavanagh, C. Howley, C. Tracey, E. Morrin, A. McDaid, A. Clarke, J.O. O'Neill, E. Joyce, M. O'Connell, N. G. Mahon   +15 more
wiley   +1 more source

Humanizing the Transgressor, Dehumanizing the Victim: The Asymmetric Effects of Transgressors’ Good Intentions in Immoral Behaviour

European Journal of Social Psychology, EarlyView.
ABSTRACT Dehumanization is a potential consequence of moral judgments that may influence how people perceive and relate to those involved in a moral transgression. We propose that a transgressor's intentions shape perceptions of both transgressors’ and victims’ humanness.
Sofía Moreno‐Gata, Ramón Rodríguez‐Torres, Verónica Betancor, Armando Rodríguez‐Pérez   +3 more
wiley   +1 more source

Rational Identification of Novel Antibody‐Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors

Advanced Science
Bystander‐killing payloads can significantly overcome the tumor heterogeneity issue and enhance the clinical potential of antibody‐drug conjugates (ADC), but the rational design and identification of effective bystander warheads constrain the broader ...
Yu Guo, Zheyuan Shen, Wenbin Zhao, Jialiang Lu, Yi Song, Liteng Shen, Yang Lu, Mingfei Wu, Qiuqiu Shi, Weihao Zhuang, Yueping Qiu, Jianpeng Sheng, Zhan Zhou, Luo Fang, Jinxin Che, Xiaowu Dong   +15 more
doaj   +1 more source

Bystander response triggered by doxorubicin-killed dead cells contributes to acquire drug resistance but increasing radiosensitivity In vitro

Journal of Radiation and Cancer Research, 2016
Introduction: A bystander effect typically refers to the death, altered growth or damage of cells that have not directly received chemotherapy or irradiation.
Abhay Puthli, Reeta Tiwari, Kaushala Prasad Mishra   +2 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

The Effect of Impartial Beneficence on Bystander Cooperation Behavior: The Roles of Social Perception and Impartial Beneficence Personality

Behavioral Sciences
Previous research on utilitarianism has focused predominantly on instrumental harm while neglecting the investigation of impartial beneficence. This study designed three progressive experiments (total n = 1378) to explore how impartial beneficence ...
Xiaodan Xu, Yingjun Zhang, Ming Yu, Hongju Li, Feng Zhang, Yan Xu   +5 more
doaj   +1 more source

Noise, Vibration, and Harshness (NVH) Challenges in Hydrogen Internal Combustion Engine Vehicles

Energy Science &Engineering, EarlyView.
ABSTRACT This paper presents a state‐of‐the‐art literature review on noise, vibration, and harshness (NVH) in hydrogen‐fuelled internal combustion engines. Studies published between 2011 and 2025 were screened, covering fundamental flame physics, test‐bench work, and recent prototype vehicles.
Krisztián Horváth
wiley   +1 more source