Results 151 to 160 of about 117,695 (339)

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

In vitro approach to the study of chronic exposure to low doses of x-rays [PDF]

, 2011
El presente trabajo fue realizado con el fin de estudiar el efecto de dosis bajas y repetidas de radiación sobre dos líneas celulares de la misma especie. Se desarrolló un modelo in vitro para evitar la influencia de los factores de confusión que afectan
Peral Garcia, Pilar, Ponzinibbio, Maria Virginia, Seoane, Analia Isabel   +2 more
core   +1 more source

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell‐of‐origin model for osteoid osteoma and osteoblastoma

The Journal of Pathology, EarlyView.
Abstract Osteoid osteoma and osteoblastoma are non‐malignant bone‐forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in osteoid osteoma and osteoblastoma.
Suk Wai Lam, Tatiana Belova, Natasja Franceschini, Brendy van den Akker, David GP van IJzendoorn, Harald MM Mikkers, Hailiang Mei, Anne‐Marie Cleton‐Jansen, Marieke L Kuijjer, Karoly Szuhai, Judith VMG Bovée   +10 more
wiley   +1 more source

The bystander effect: Impact of rural hospital closures on the operations and financial well-being of surrounding healthcare institutions. [PDF]

J Hosp Med, 2022
Ramedani S, George DR, Leslie DL, Kraschnewski J.   +3 more
europepmc   +1 more source

Unraveling the direct and indirect effects of interpersonal mindfulness on school‐age bullying perpetration and victimization: The mediating role of emotional intelligence

Pediatric Investigation, EarlyView.
Emotional intelligence mediated the association between interpersonal mindfulness and bullying victimization/perpetration (BV/BP). Higher interpersonal mindfulness was significantly associated with higher emotional intelligence. Higher emotional intelligence was significantly associated with lower BV/BP.
Marguerita Aoun, Elias Saade, Abdallah Chahine, Georges Maalouf, Abdo Hankache, Sahar Obeid, Feten Fekih‐Romdhane, Souheil Hallit   +7 more
wiley   +1 more source

Spatially fractionated radiotherapy versus conventional radiotherapy in the treatment of soft tissue sarcoma: A multicenter, prospective, phase II, randomized controlled clinical trial protocol

Precision Radiation Oncology, EarlyView.
The first randomized controlled trial comparing spatially fractionated radiotherapy (SFRT) with conventional radiotherapy (CRT) for soft tissue sarcoma (STS) will evaluate efficacy and safety, offering critical evidence to optimize treatment strategies.
Peng Shang, Minghao Li, Xiang Zhang, Dongyuan Zhu, Jinbo Yue   +4 more
wiley   +1 more source

Establishment and Comparative Analysis of Radiation‐Induced Liver Disease in Normal and Fibrotic Rat Models

Precision Radiation Oncology, EarlyView.
This study successfully established two novel rat models of radiation‐induced liver disease (RILD), one in healthy livers and the other in TAA‐induced fibrotic livers, providing valuable insights into the combined effects of radiation and pre‐existing fibrosis.
Yanting Jiang, Yuxi Ding, Fang Wang, Danni Chen, Weixiang Zhong, Zhongjie Lu, Yixiang J. Wang, Senxiang Yan, Xiaoguang Liu, Feng Zhao   +9 more
wiley   +1 more source

Near-infrared-induced drug release from antibody-drug double conjugates exerts a cytotoxic photo-bystander effect. [PDF]

Bioeng Transl Med, 2022
Takahashi K, Yasui H, Taki S, Shimizu M, Koike C, Taki K, Yukawa H, Baba Y, Kobayashi H, Sato K.   +9 more
europepmc   +1 more source

46. Adenoviral-Mediated Gene Transfer of Single Chain Fv 425:sTRAIL Fusion Protein Induces Target Cell Restricted Apoptosis in EGFR-Positive Tumor Cells and a Potent Bystander Effect without Toxicity In Vivo

, 2007

openalex   +1 more source

Why Autonomous Vehicles Are Not Ready Yet: A Multi‐Disciplinary Review of Problems, Attempted Solutions, and Future Directions

Journal of Field Robotics, EarlyView.
ABSTRACT Personal autonomous vehicles can sense their surrounding environment, plan their route, and drive with little or no involvement of human drivers. Despite the latest technological advancements and the hopeful announcements made by leading entrepreneurs, to date no personal vehicle is approved for road circulation in a “fully” or “semi ...
Xingshuai Dong, Massimiliano Cappuccio, Fady Alnajjar, Luqman Ali, Hamad Al Jassmi, Essam Debie, Milad Ghasrikhouzani, Alessandro Lanteri, Tate McGregor, Oleksandra Molloy, Alice Plebe, Michael Regan, Eduardo Sandoval, Dongmo Zhang   +13 more
wiley   +1 more source