Results 41 to 50 of about 117,695 (339)

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

A Role for Bioelectric Effects in the Induction of Bystander Signals by Ionizing Radiation?

Dose-Response, 2007
The induction of “bystander effects” i.e. effects in cells which have not received an ionizing radiation track, is now accepted but the mechanisms are not completely clear.
C. Mothersill PhD, G. Moran PhD, F. McNeill PhD, M.D. Gow BSc, J. Denbeigh, W. Prestwich PhD, C.B. Seymour PhD   +6 more
doaj   +1 more source

Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation

BMC Cancer, 2008
Background Radiation-induced bystander responses, where cells respond to their neighbours being irradiated are being extensively studied. Although evidence shows that bystander responses can be induced in many types of cells, it is not known whether ...
Held Kathryn D, Folkard Melvyn, Shao Chunlin, Prise Kevin M   +3 more
doaj   +1 more source

Radiation-Induced Rescue Effect: Insights from Microbeam Experiments

Biology, 2022
The present paper reviews a non-targeted effect in radiobiology known as the Radiation-Induced Rescue Effect (RIRE) and insights gained from previous microbeam experiments on RIRE.
Kwan Ngok Yu
doaj   +1 more source

Bystander Effects

, 2023
AbstractThe lesson from research on the bystander effect is that the more people who are present when a verbal intervention is required to change the course of events in a positive way, the less likely it is that anyone will speak up. Although exceptions occur, where a high number of bystanders can increase the likelihood of intervention, the main ...
openaire   +1 more source

Local symmetry properties of pure 3-qubit states [PDF]

, 2000
Entanglement types of pure states of 3 qubits are classified by means of their stabilisers in the group of local unitary operations. It is shown that the stabiliser is generically discrete, and that a larger stabiliser indicates a stationary value for ...
A Sudbery, Bennett C H, Coffman V, Coffman V, Grassl M, H A Carteret, Horodecki M, Linden N, Lo H K, Nielsen M A, Popescu S, Schlienz J, Schrödinger E, Thapliyal A V, Vidal G, Vinberg E B   +15 more
core   +7 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Layanan Bimbingan Kelompok Melalui Permainan Simulasi Shadow Puppet Untuk Mengurangi Tingkat Bystander Effect Siswa

Teraputik: Jurnal Bimbingan dan Konseling
Bystander effect diartikan sebagai kondisi seseorang yang hanya menjadi penonton terhadap suatu peristiwa darurat, namun tidak melakukan tindakan apapun karena kehadiran orang lain, tanpa memandang lokasi maupun waktu.
Mufarochah Imro'atu Sholihah, Khairul Bariyyah, Leny Latifah   +2 more
doaj   +1 more source

Booze, Bars, and Bystander Behavior: People who Consumed Alcohol Help Faster in the Presence of Others.

Frontiers in Psychology, 2016
People help each other less often and less quickly when bystanders are present. In this paper, we propose that alcohol consumption could attenuate or reverse this so-called bystander effect.
Marco eVan Bommel, Marco eVan Bommel, Jan-Willem eVan Prooijen, Henk eElffers, Paul evan Lange   +4 more
doaj   +1 more source