Results 61 to 70 of about 117,695 (339)

γ-H2AX foci as in vivo effect biomarker in children emphasize the importance to minimize x-ray doses in paediatric CT imaging [PDF]

, 2014
Objectives: Investigation of DNA damage induced by CT x-rays in paediatric patients versus patient dose in a multicentre setting. Methods: From 51 paediatric patients (median age, 3.8 years) who underwent an abdomen or chest CT examination in one of the
A. De Backer, C. Ernst, C. Franck, C. Vandevoorde, H. Thierens, K. Bacher, K. Van De Moortele, L. Breysem, M. H. Smet, P. Smeets   +9 more
core   +2 more sources

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Investigation of the expression of P53 gene in bystander cells after therapeutic ultrasound exposure

Fiyz̤, 2019
Background: Bystander effect is defined as biological responses observed in cells that are not exposed to radiation directly but these radiation effects are induced through messages from irradiated cells.
Rezaei M, Kamran-Samani R, Shanei A, Kazemi M, Hejazi SH   +4 more
doaj  

Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model

Translational Oncology, 2021
Locally advanced rectal cancer is treated with neoadjuvant-chemoradiotherapy, however only 22% of patients achieve a complete response. Resistance mechanisms are poorly understood.
Aisling B. Heeran, Helen P. Berrigan, Croí E. Buckley, Heleena Moni Bottu, Orla Prendiville, Amy M. Buckley, Niamh Clarke, Noel E. Donlon, Timothy S. Nugent, Michael Durand, Cara Dunne, John O. Larkin, Brian Mehigan, Paul McCormick, Lorraine Brennan, Niamh Lynam-Lennon, Jacintha O'Sullivan   +16 more
doaj   +1 more source

Dynamics of Helping Behavior and Networks in a Small World

, 2006
To investigate an effect of social interaction on the bystanders' intervention in emergency situations a rescue model was introduced which includes the effects of the victim's acquaintance with bystanders and those among bystanders from a network ...
A. T. Bernardes, B. Latané, D. J. Watts, Hang-Hyun Jo, Hie-Tae Moon, J. A. Hołyst, J. A. Piliavin, J. Scott, R. N. Mantegna, Woo-Sung Jung   +9 more
core   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

To Ignore, to Join in, or to Intervene? Contextual and Individual Factors Influencing Cyber Bystanders’ Response to Cyberbullying Incidents

Children
Background/Objectives: Cyber bystanders can choose from several different strategies during cyberbullying incidents and have a significant effect on the situation.
Nikolett Arató, Lilla Németh, Peter J. R. Macaulay   +2 more
doaj   +1 more source

DNA damage and survival in bystander human intestinal cells treated with conditioned medium from tritium-labeled cells

Journal of Radiation and Cancer Research, 2020
Background: Tritium exposure could be one of the radiation hazards in case of accidental exposure with intestine as one of the major target organs. In the cells, low-energy beta emitted from tritium would traverse a very short distance (a few microns ...
Manjoor Ali, Vasumathy Rajan, Badri Narain Pandey   +2 more
doaj   +1 more source

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation [PDF]

, 2007
The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1).
Ben J. C. Quah, Christopher R. Parish, Klaus I. Matthaei, Mark D. Hulett, Vaughan P. Barlow, Virginia McPhun   +5 more
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source