Results 111 to 120 of about 3,678,468 (242)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

El rol de la cirugía en el manejo integral del cáncer de colon: ¿dónde estamos y hacia dónde vamos?

Revista de Cirugía Colorrectal
El cáncer de colon es actualmente la primera causa de muerte por cáncer; por ello, la atención médica debe estandarizarse desde el primer nivel de atención hasta los centros médicos de tercer nivel. El tratamiento quirúrgico del cáncer de colon es fundamental, ya sea en enfermedad localizada o metastásica. Como la mayoría de los pacientes (hasta el 70%)
Mónica P. Hernández-Molina, Sergio U. Pérez-Escobedo, Diego R. Mendoza-Díaz, Christhopher Flores-Rivera, Cristian J. Flores-González, Juan A. Villanueva-Herrero, Itzel Vela-Sarmiento, Billy Jiménez-Bobadilla, Noelia B. Fernández-Baez, Sharon J. Sánchez-Lara, Angie Vargas-Rodríguez, Carlos A. López-Bernal   +11 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cancer Immunotherapy: lights and shadows

Frontiers in Immunology, 2015
María Marcela eBarrio, Estrella Mariel Levy, José Maria Mordoh, José Maria Mordoh   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential Effects of a Telemonitoring Platform in the Development of Chemotherapy-Associated Toxicity: A Randomized Trial Protocol

Diagnostics
Chemotherapy requires careful monitoring, but traditional follow-up approaches face significant challenges that were highlighted by the COVID-19 pandemic. Hence, exploration into telemonitoring as an alternative emerged.
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi   +5 more
doaj   +1 more source

Análisis de las características clínicas y resultados de cirugía en pacientes con cáncer colorrectal en un hospital de tercer nivel en México tras regular la atención hospitalaria por la emergencia sanitaria de COVID-19

Revista de Cirugía Colorrectal
Objetivo: El cáncer colorrectal (CCR) figura como la tercera neoplasia más frecuente a nivel mundial. Sin embargo, la atención médica de esta enfermedad se vio interrumpida durante la pandemia de COVID-19, lo que ocasionó retrasos en el diagnóstico y tratamiento del CCR.
Abelardo Juanz-González, Samanta K. Dosal-Limón, Alejandro Vela-Torres, Billy Jiménez-Bobadilla, Juan A. Villanueva-Herrero, Gerardo J. Maya-Vacío, Ana J. Iberri-Jaime, Jorge L. De León-Rendón   +7 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Effects on Quality of Life of a Telemonitoring Platform amongst Patients with Cancer (EQUALITE): A Randomized Trial Protocol

Methods and Protocols
Cancer, a pervasive global health challenge, necessitates chemotherapy or radiotherapy treatments for many prevalent forms. However, traditional follow-up approaches encounter limitations, exacerbated by the recent COVID-19 pandemic.
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source