Results 111 to 120 of about 3,877,567 (286)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice
Cell Communication and SignalingBackground HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a significant lung maturation delay.
Rocío Fuentes-Mateos +8 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Cancer cases detected in the prevention and control service of a private cancer clinic in Peru
Infectious Agents and Cancer, 2019 Purpose Describe the characteristics of patients seen at the Cancer Prevention and Control Service at a Peruvian private cancer clinic in 2014.
José Revilla-López +13 more
doaj +1 more source
Mortalidad por cáncer oral en Chile entre los años 2002-2012 [PDF]
, 2015 Tesis (Cirujano Dentista, Grado de Magíster en Ciencias Odontológicas)En Chile desde 1970 el cáncer es la 2a causa de muerte, siendo el cáncer oral un problema de salud de alcance mundial, según lo indica la OMS.
Candia Rojas, Jorge, Kraemer Meza, Kim
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Biological role of NK cells and immunotherapeutic approaches in breast cancer
Frontiers in Immunology, 2012 In recent decades, tumor surveillance by the immune system and its impact on disease outcomes in cancer patients in general and in breast cancer (BC) patients in particular has been documented.
María Paula Roberti +3 more
doaj +1 more source
, 2008 El Cáncer bucal y bucofaríngeo representa el 3% de todos los canceres, sin embargo, son de los que menor tasa de sobre vida a 5 años presentan. Los canceres bucales son diagnosticados en estadios avanzados en un 68-72% de los casos, lo cual en muchas ...
Alemán Navas, Ramón Manuel +2 more
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