Results 91 to 100 of about 3,678,468 (242)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Biological role of NK cells and immunotherapeutic approaches in breast cancer

Frontiers in Immunology, 2012
In recent decades, tumor surveillance by the immune system and its impact on disease outcomes in cancer patients in general and in breast cancer (BC) patients in particular has been documented.
María Paula Roberti, José eMordoh, José eMordoh, Estrella Mariel Levy   +3 more
doaj   +1 more source

Cáncer colorrectal sincrónico con resección multisegmentaria: desafíos diagnósticos y terapéuticos. Reporte de caso

Revista de Cirugía Colorrectal
El cáncer colorrectal múltiple es una afección rara, con controversias actuales en su diagnóstico y manejo dados los pocos reportes en la literatura. Se presenta el caso de un paciente de 58 años, sin antecedentes de relevancia, que acude al servicio de urgencias por un cuadro de hematoquecia y pérdida de peso.
Jessica Capre-Pereira, Helber F. Pérez-Imbachí, Karen Ponce, Juan G. Holguín-Henao, Sandra M. Gutiérrez-Cañas, Alejandro Caballero, Abraham Kestenberg   +6 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Diseño y métodos de un estudio de la historia natural de la neoplasia de cuello uterino en la población de una provincia rural de Costa Rica: el Proyecto de Guanacaste

Revista Panamericana de Salud Pública
En este documento se informa sobre la fase de inscripción de un estudio de la historia natural de la neoplasia de cuello uterino basado en la población de Guanacaste, una provincia rural de Costa Rica con tasas constantemente elevadas de cáncer ...
Rolando Herrero, Mark H. Schiffman, Concepción Bratti, Allan Hildesheim, Ileana Balmaceda, Mark E. Sherman, Mitchell Greenberg, Fernando Cárdenas, Víctor Gómez, Kay Helgesen, Jorge Morales, Martha Hutchinson, Laurie Mango, Mario Alfaro, Nancy W. Potischman, Sholom Wacholder, Christine Swanson, Louise A. Brinton   +17 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Activación conductual y mindfulness en la experiencia del dolor de mujeres con cáncer de mama

Gaceta Mexicana de Oncología
Antecedentes: El dolor relacionado con cáncer es una experiencia multifactorial que puede afectar en la adherencia al tratamiento y generar malestar psicológico. Los tratamientos psicológicos constantemente usados buscan disminuir tal malestar sin considerar las necesidades adaptativas de las personas con cáncer. Es necesario implementar intervenciones
Mayra García-Reyes, Alejandra Cruz-Martínez, Rosa P. Figuerola-Escoto   +2 more
openaire   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source