Results 141 to 150 of about 355,520 (263)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Uptake of cervical cancer screening and associated factors among human immune virus positive women attending antiretroviral therapy clinic in public health facilities, Northeast Ethiopia, 2022: A cross-sectional study

SAGE Open Medicine
Background: Although cervical cancer is the most prevalent cancer in women and has a high morbidity, mortality, and low quality of life burden among human immune virus-positive women, there is little evidence of it in northeastern Ethiopia.
Yemane Eshetu Bekalu, Muluken Amare Wudu, Amare Workie Gashu   +2 more
doaj   +1 more source

Conhecimentos sobre o papiloma vírus humano (HPV) e cancro do colo do útero (CCU): estudo exploratório em estudantes da área da saúde do ensino superior [PDF]

, 2017
A nível mundial, o cancro do colo do útero é a segunda causa de morte das mulheres estando, em regra, associado à infeção pelo Vírus do Papiloma Humano (HPV). Verifica-se uma elevada prevalência de infeções por este agente em jovens com atividade sexual,
Baptista, Gorete, Costa, Cátia Sofia Afonso, Galvão, Ana Maria, Gomes, Maria José, Pinheiro, Marco   +4 more
core  

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

The predictive value of miR-29b-2-5p on the prognosis of cervical cancer and its inhibitory effect on cervical cancer progression

The International Journal of Biological Markers
Objective The poor prognosis of cervical cancer patients leads to an annual increase in mortality, while microRNAs are involved in various cancers, including cervical cancer.
Qinghan Liu, Xi Chen, Wenhui Zhang, Wei Shang, Jinwei Cao, Huijuan Zhao, Feng Jian   +6 more
doaj   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Estrategias comunitarias para la detección temprana del cáncer de cuello uterino en mujeres indígenas en edad reproductiva del cantón Pelileo

Correo Científico Médico
El cáncer de cuello uterino constituye una de las principales causas de morbilidad y mortalidad en mujeres en edad fértil, especialmente en poblaciones vulnerables como las comunidades indígenas.
Silvia Alexandra Laica Sailema, Ylsy Thibisay Guevara García, Mónica Gabriela Cháchalo Sandoval   +2 more
doaj  

Prueba de detección del ADN de VPH de alto riesgo mediante Test de Captura Híbrida 2: su utilidad en el tamizaje del cáncer cervicouterino en atención primaria en San Vicente, El Salvador [PDF]

, 2016
Esta investigación bibliográfica se realiza con el objetivo de comprobar la utilidad del Test de Captura Híbrida 2 (HC2) en el tamizaje primario del virus del papiloma humano (VPH) y la detección del cáncer cervicouterino en pacientes del municipio de ...
Alemán Rodríguez, Carlos Jaime, Corvera Calderón, Roxana Margarita, Cruz Barrera, Mario René   +2 more
core  

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source