Results 51 to 60 of about 58,752,357 (236)
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2012 Objetivo: presentar dos casos de pacientes con cáncer de cérvix estadios IA2, con deseos de paridad, que fueron sometidas a traquelectomía radical vaginal como cirugía conservadora de la fertilidad, y realizar una revisión de la literatura científica ...
Carlos Giovani Castro-Cuenca +4 more
doaj
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Dosis y fraccionamientos en braquiterapia en el cáncer de cérvix; a propósito de un caso [PDF]
, 2022 El cáncer de cuello uterino es la 4º neoplasia más frecuente en mujeres a nivel mundial siendo la tasa de mortalidad 18 veces mayor en los países de ingresos bajos o medios respecto a los países ricos debido a su gran relación con la infección por el ...
Ruiz Montero, Irene
core
Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran +13 more
wiley +1 more source
Salud Uninorte, 2008 Objetivo: Determinar prevalencia de uso de la citología vaginal en mujeres de 18 a 65 años de edad afiliadas al régimen subsidiado y atendidas en la Unidad Hospitalaria La Manga de Barranquilla.
Edgar Navarro Lechuga +1 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Terapéutica del cáncer de cuello uterino, una revisión de la literatura [PDF]
, 2018 Introducción. El cáncer de cuello uterino es la segunda causa de muerte más frecuente mundialmente; por ello, existen terapias tanto invasivas como poco invasivas que buscan impactar la supervivencia de la enfermedad. Entre
Suárez-Cadena, Fabio Camilo
core +1 more source
Arthritis Care &Research, EarlyView.Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin +7 more
wiley +1 more source