Results 71 to 80 of about 58,752,357 (236)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Cáncer de Cuello de Útero: estrategias de Prevención [PDF]

, 2016
Introducción: El cáncer de cérvix es el tercer cáncer más frecuente en la población femenina; y es considerado una secuela a largo plazo de la infección persistente del Virus del Papiloma Humano, su principal factor etiológico.
Gutiérrez Sainz de Aja, Elena
core  

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Promoción y prevención del cáncer de cérvix en Huancayo [PDF]

, 2015
The study goal was raising awareness in the Incho neighborhood, El Tambo district from Huancayo about cervical cancer prevention, and also spread this awareness to the population on the importance of Papanicolau smear screening.
Ribbeck Soto, Leticia, Mejia Cuyatti, Arleth, Romero Manrique, Nataly   +2 more
core   +1 more source

Presencia del marcador p16 en biopsias cervicales dirigidas bajo colposcopia, en mujeres que asisten a la Clinica Maternidad Rafael Calvo de Cartagena, con resultados de citología anormal

Revista Ciencias Biomédicas, 2011
OBJETIVO: determinar la presencia por inmuno - histoquímica, del marcador P16INK4a, en biopsias cervicales dirigidas bajocolposcopia, en mujeres con resultados de citología anormal, que asisten a la consulta de colposcopia de la Clínica Maternidad ...
Barrios-García Lía, Borré-Arrieta Orlando, Arroyo- Salgado Bárbara, Benedetti-Padrón Inés, Martínez- Lugo Juan, Alvis -Estrada Luis   +5 more
doaj  

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

¿Preservación de la fertilidad en cáncer de cérvix? Es posible

, 2013
El cáncer de cérvix es la causa más común de muerte por cáncer ginecológico en el mundo. Debido al incremento del diagnóstico de esta enfermedad en estadios tempranos en mujeres en edad fértil, hacemos énfasis en los nuevos conceptos de preservación de ...
B, Aldo López, L, Manuel Álvarez, Santos-Ocaña, Carlos, T, Magaly Malca   +3 more
core  

El cáncer de cérvix en el embarazo: diagnóstico, evolución y tratamiento [PDF]

, 2020
INTRODUCCIÓN: El cáncer de cérvix es hoy en día una de las neoplasias que se diagnostican de forma más frecuente durante el embarazo. Esto no es debido a que el embarazo se considere un factor precipitante para el cáncer de cérvix, sino a que a muchas ...
Melero Ciprés, María Ibón, González Navarro, José Vicente   +1 more
core  

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source