Results 131 to 140 of about 222,078 (214)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Correction: Ribeiro et al. Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 6728. [PDF]

Int J Mol Sci
Ribeiro N, Albino M, Ferreira A, Escrevente C, Barral DC, Pessoa JC, Reis CP, Gaspar MM, Correia I.   +8 more
europepmc   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Ten-Year Outcomes in Colorectal Cancer-Competing Risks and Patient Vulnerability: A Prospective Multicenter Observational Study. [PDF]

J Clin Med
García-Aranda M, Martín-García D, Gallejones-Eskubi J, Urrechaga E, Ferreiro J, Portugal V, Portillo I, Jiménez-Toscano M, Legarreta MJ, Quintana JM, Redondo M, Aguirre U, REDISSEC/CARESS-CCR Group.   +12 more
europepmc   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

Added value of adjuvant chemotherapy in patients with node-positive pT1-2 colon cancer: a national SNAPSHOT analysis. [PDF]

Oncologist
Hanevelt J, de Groot JWB, Rademaker E, Zamaray B, Brohet RM, Moons LMG, Vleggaar FP, Consten ECJ, Tanis PJ, de Vos tot Nederveen Cappel WH, van Westreenen HL, Dutch Snapshot Research Group (DSRG), Dutch Complex Colon Cancer Initiative (DCCCI) and Collaborators Snapshot Registry.   +12 more
europepmc   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, EarlyView.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

TOP2 and NOS2 Orchestrate the Generation of DNA Breaks to Promote Colitis Cancer Initiation. [PDF]

Cancers (Basel)
Chang TK, Li SL, Brunac AC, Huang JJ, Yeh YH, Brousset P, Egly JM, Li TK.   +7 more
europepmc   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

A Hybrid Lung and Colon Histopathological Image Classification Framework Using MobileNetV3-Small Deep Features and Differential Evolution Optimization. [PDF]

Diagnostics (Basel)
Naveed MU, Jabbar S, Iqbal MM, Ahmad A, Alkhazi IS, Alghamdi M.   +5 more
europepmc   +1 more source