Results 141 to 150 of about 183,594 (330)

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

open access: yesAdvanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin   +11 more
wiley   +1 more source

MAMA: Meta-optimized Angular Margin Contrastive Framework for Video-Language Representation Learning [PDF]

open access: yesarXiv
Data quality stands at the forefront of deciding the effectiveness of video-language representation learning. However, video-text pairs in previous data typically do not align perfectly with each other, which might lead to video-language representations that do not accurately reflect cross-modal semantics. Moreover, previous data also possess an uneven
arxiv  

Modeling Multi-mode D2D Communications in LTE [PDF]

open access: yesarXiv, 2014
In this work we propose a roadmap towards the analytical understanding of Device-to-Device (D2D) communications in LTE-A networks. Various D2D solutions have been proposed, which include inband and outband D2D transmission modes, each of which exhibits different pros and cons in terms of complexity, interference, and spectral efficiency achieved. We go
arxiv  

Subtipado molecular del cáncer de mama masculino con PAM50: Correlación con el subtipaje inmunohistoquímico y estudio de supervivencia. [PDF]

open access: yes, 2017
Introducción: El cáncer de mama masculino es una enfermedad rara aún poco conocida, que principalmente corresponde a subtipo luminal usando la clasificación molecular subrogada a inmunohistoquímica.
Alba-Conejo, Emilio   +9 more
core  

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

open access: yesAdvanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu   +13 more
wiley   +1 more source

[Construction and validation of a video about breast cancer for deaf womenConstrucción y validación de un video sobre el cáncer de mama para mujeres sordas]. [PDF]

open access: yesRev Cuid, 2023
Pereira-Gomes JD   +5 more
europepmc   +1 more source

Asymptotic behaviour of instantons on Cylinder Manifolds [PDF]

open access: yesarXiv, 2018
IIn this article, we study the instanton equation on the cylinder over a closed manifold $X$ which admits non-zero smooth $3$-form $P$ and $4$-form $Q$. Our results are (1) if $X$ is a \textbf{good} manifold, i.e., $P,Q$ satisfying $d\ast_{X}P=d\ast_{X}Q=0$, then the instanton with integrable curvature decays exponentially at the ends, and, (2) if $X ...
arxiv  

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee   +5 more
wiley   +1 more source

ESTRATIFICACIÓN DE LA MORTALIDAD POR CÁNCER DE MAMA, COLON Y PULMÓN EN POBLACIÓN FEMENINA

open access: yesMedicentro, 2012
Introducción: El cáncer constituye un serio problema de salud. Objetivo: Determinar la mortalidad por cáncer de mama, colon y pulmón en la población femenina, según estratos demográficos.
Noira Durán Morera   +3 more
doaj  

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