Results 141 to 150 of about 393,854 (363)

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

open access: yesAdvanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang   +16 more
wiley   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang   +10 more
wiley   +1 more source

Factores predictivos de recaída sistémica y supervivencia cáncer-específica tras recaída locorregional en cáncer de mama resecado [PDF]

open access: yes, 2012
S'ha realitzat un anàlisi retrospectiu de variables clínic-patològiques d'una sèrie de 116 malaltes diagnosticades d'una recaiguda locorregional de càncer de mama després d'una resecció quirúrgica amb mastectomía o cirurgía conservadora a l'Hospital ...
Galcerán, Joan Carles   +3 more
core  

CÂNCER DE MAMA: FATORES DE RISCO E DETECÇÃO PRECOCE

open access: yesAnais do I Congresso Nacional On-line Multidisciplinar de Saúde da Mulher, 2023
Fernanda de Queiroz Albuquerque   +2 more
semanticscholar   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

open access: yesAdvanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang   +8 more
wiley   +1 more source

Abordaje enfermero en pacientes con cáncer de mama en tratamiento con Tamoxifeno [PDF]

open access: yes, 2019
Introducción: La sociedad actual está muy sensibilizada con las mujeres que padecen cáncer de mama, pero poco se trata el problema de salud que presentan determinados tratamientos como es el caso del Tamoxifeno, fármaco usado para evitar el aumento de la
Román Sánchez, Paula
core  

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

open access: yesAdvanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu   +9 more
wiley   +1 more source

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