Results 121 to 130 of about 16,806 (224)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Synthesis and Characterization of Novel Silylated Sm3+ and Eu3+ Complexes Incorporated Into Mesoporous Silica Nanoparticles

European Journal of Inorganic Chemistry, EarlyView.
The strategy of incorporating the Eu(tta‐Si)3(phen) and Sm(tta‐Si)3(phen)2 complexes prevented leaching of the complexes and preserved their intrinsic optical properties. Preliminary studies of silylated Ln3+ complexes and nanoparticles loaded with these complexes demonstrated cytotoxicity against cancer cells, with minimal cytotoxic effect on nontumor
Juliana Jorge, Jaqueline Rodrigues da Silva, Diego Boldo, Kristiane Fanti Del Pino Santos, Luana da Silva Oliveira, Adriana Pereira Duarte, Gustavo Rocha de Castro, Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Marc Verelst, Vasilii Khripun, Marco Antonio Utrera Martines   +11 more
wiley   +1 more source

Cáncer de mama. Tratamiento conservador

Cirugía del Uruguay, 1989
Se analizan 45 casos de cáncer de mama estadios I y· 11, tratados con procedimientos conservadores. Las pacientes fueron seleccionadas de un total de 894 casos procedentes del área de la asistencia médica colectivizada, asistidas y controladas por el ...
Graciela Sabini, Ignacio Musé, Roberto Notejane, Alberto Viola, Graciela Pees   +4 more
doaj  

CÁNCER HEREDITARIO DE MAMA

Revista Chilena de Radiología
En cáncer de mama, aproximadamente el 10% de los casos corresponde a síndromes hereditarios. Una porción significante de estos, un 30%, se atribuye a la herencia de mutaciones en genes BRCA1 y BRCA2 característico del síndrome de cáncer de mama y/u ...
Sonia Margarit
doaj   +1 more source

Strategic construction of fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents for amplifying cancer phototheranostics

FlexMat, EarlyView.
The development of conventional phototheranostic nanomedicines suffers from an intrinsic trade‐off between NIR‐II fluorescence emission and phototherapeutic effects, leading to poor overall efficacy. Herein, we propose an innovative fluorination strategy by constructing fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents to ...
Xiaoming Hu, Achen Qin, Caijun Zhu, Jinshuo Mi, Zejing Chen, Jiaying Shao, Zhen Li, Zhen Yang   +7 more
wiley   +1 more source

Mujeres con diagnóstico de cáncer de mama: Abordaje psicodinámico.

, 2019
Resumen El cáncer es la segunda causa de muerte a nivel nacional y el de mama es uno de los de mayor incidencia en las mujeres. El objetivo general del estudio fue Identificar los procesos psíquicos subyacentes, mecanismos de defensa, necesidades y ...
Fernández, María
core  

Situación del cáncer de mama en la región de Azuero

Breast cancer in the Azuero region has a high percentage in adult women, who after collecting data and medical consultations with at least 96 breast cancer patients, and among the factors, we can mention the highest incidence are: genetic factor, lack of
Mendoza, Julia, Bustavino, Paola, Castillo, Alisson, Sandoval, Nataly, Solis, Osvaldo, Rodríguez, Johnny, Baltazar, Jahir   +6 more
core   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

Criterio terapéutico moderno de los cánceres de mama

Cirugía del Uruguay, 1979
Los autores exponen los nuevos conceptos terapéuticos del cáncer de mama en función de factores inmunológicos, la detección precoz con la radiografía, diafanografía y la punción citológica, el diagnóstico más exacto de la extensión de la neoplasia ...
Alberto Valls, Boris Asiner, Ricardo Mayol   +2 more
doaj