Results 91 to 100 of about 5,139,728 (295)

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Magnetic Resonance Guided Radiotherapy for Rectal Cancer: Expanding Opportunities for Non-Operative Management

Cancer Control, 2020
Colorectal cancer is the third most common cancer in men and the second most common in women worldwide, and the incidence is increasing among younger patients. 30% of these malignancies arise in the rectum.
Leila T. Tchelebi MD, Paul B. Romesser MD, Sebastian Feuerlein MD, Sarah Hoffe MD, Kujtim Latifi PhD, Seth Felder MD, Michael D. Chuong MD   +6 more
doaj   +1 more source

Long-term Oncological and Functional Outcomes of Chemoradiotherapy Followed by Organ-Sparing Transanal Endoscopic Microsurgery for Distal Rectal Cancer: The CARTS Study

JAMA Surgery, 2019
Importance Treatment of rectal cancer is shifting toward organ preservation aiming to reduce surgery-related morbidity. Short-term outcomes of organ-preserving strategies are promising, but long-term outcomes are scarce in the literature.
Rutger C. H. Stijns, E. D. de Graaf, C. Punt, I. Nagtegaal, J. Nuyttens, E. van Meerten, P. Tanis, I. D. de Hingh, G. P. van der Schelling, Y. Acherman, J. Leijtens, A. Bremers, G. Beets, C. Hoff, C. Verhoef, C. Marijnen, J. D. de Wilt   +16 more
semanticscholar   +1 more source

¿Es el cribado del PSA un método efectivo para la prevención y detección del cáncer de próstata en varones mayores de 50 años? [PDF]

, 2017
Tras el descubrimiento del antígeno prostático específico (PSA), este antígeno se ha generalizado como indicador para el cribado poblacional del cáncer de próstata en las consultas de Atención Primaria.
Ruiz Vázquez, Julia
core  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

El drenaje pélvico en la escisión total del mesorrecto, un estudio multicéntrico paneuropeo [PDF]

, 2017
Antecedents. Aunque existe un buen nivel de evidencia respecto a la inefectividad de la colocación de un drenaje pélvico profiláctico después de las cirugías de resección de colon, todavía existe controversia en las cirugías de escisión del mesorrecto ...
de la Rosa Estadella, Marta, Universitat Autònoma de Barcelona. Facultat de Medicina   +1 more
core  

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Immediate results of combined and multivisceral resections for rectal cancer

Сибирский онкологический журнал, 2019
Background. Currently, the indications for multivisceral pelvic resections have increased dramatically. However, short-and long-term outcomes after these resections for locally advanced rectal cancer remain a subject of debate.The purpose of the study ...
S. G. Afanasyev, A. Yu. Dobrodeev, I. B. Khadagaev, S. A. Fursov, E. A. Usynin, А. S. Tarasova, D. A. Sorokin, V. V. Faltin, A. V. Usova   +8 more
doaj   +1 more source

Role of aspirin in cancer prevention.

Cancer Treatment and Research Communications
Aspirin [1], also known as acetylsalicylic acid, is a common non-steroidal anti-inflammatory drug (NSAID). The available evidence shows that aspirin can effectively prevent and treat diseases such as rectal, gastric, ovarian, prostate, and lung cancer ...
Meng Sun, Jun Yu, Jie Wan, Xiaoyun Dou, Xiaoying Chen, Fang Ye   +5 more
semanticscholar   +1 more source