Results 101 to 110 of about 5,139,728 (295)

Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Annals of Oncology, 2018
Department of Radiotherapy, Mount Vernon Centre for Cancer Treatment, Northwood, London, UK; Department of Gastrointestinal Cancer, Maria SklodowskaCurie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Department of Surgery, Sorbonne ...
R. Glynne-Jones, L. Wyrwicz, E. Tiret, G. Brown, C. Rödel, A. Cervantes, D. Arnold   +6 more
semanticscholar   +1 more source

Tratamiento quirúrgico de las fístulas rectales complejas usando la técnica de transposición de músculo gracilis [PDF]

, 2013
Las fístulas son uniones anormales entre un órgano, un vaso o el intestino y otra estructura. Las fístulas entre el recto y la uretra o entre el recto y la vagina, tienen diferentes etiologías, raramente son congénitas, en la mayoría de casos son ...
Sierra Jaramillo, Jorge Iván
core  

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Safety and Feasibility of Using Magnetic Resonance Imaging Criteria to Identify Patients With "Good Prognosis" Rectal Cancer Eligible for Primary Surgery: The Phase 2 Nonrandomized QuickSilver Clinical Trial.

JAMA Oncology, 2019
Importance Chemoradiotherapy (CRT), followed by surgery, is the recommended approach for stage II and III rectal cancer. While CRT decreases the risk of local recurrence, it does not improve survival and leads to poorer functional outcomes than surgery ...
E. Kennedy, M. Šimunović, K. Jhaveri, R. Kirsch, J. Brierley, S. Drolet, C. Brown, P. Vos, W. Xiong, T. MacLean, S. Kanthan, P. Stotland, S. Raphael, Gil Chow, Catherine O’Brien, C. Cho, C. Streutker, R. Wong, S. Schmocker, S. Liberman, C. Reinhold, N. Kopek, V. Marcus, A. Bouchard, C. Lavoie, S. Morin, M. Périgny, A. Wright, Katerina Neumann, S. Clarke, N. Patil, T. Arnason, L. Williams, R. McLeod, G. Brown, A. Mathieson, A. Pooni, N. Baxter   +37 more
semanticscholar   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Estudio Farmacogenético En Pacientes Con Carcinoma Rectal Tratados Con Quimorradioterapia Neoadyuvante Basada En Capecitabina [PDF]

, 2012
Estudio de los polimorfismos del gen de la timidilato sintasa y los genes reparadores del ADN ERCC1 y XRCC1 y su relación con la rdespuesta al tratamiento neoadyvante con qumiorradioterapia basada en capecitabin, en pacientes afecto de carcinoma ...
Sebio Garcia, Ana, Universitat Autònoma de Barcelona. Departament de Medicina, Universitat Autònoma de Barcelona. Facultat de Medicina   +2 more
core  

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

QoL de doentes com cancro do recto localmente avançado: QRT pré-operatória [PDF]

, 2013
O cancro colo-rectal é o terceiro tipo de cancro mais comum em ambos os sexos. Os factores ambientais, o sedentarismo, a obesidade, o tabagismo, o álcool, uma dieta rica em carne vermelha e pobre em fibras, desempenham um forte papel na etiologia do ...
Coelho, Carina Marques, Farinha, Camila, Monsanto, Fátima, Moreira, Ana Catarina, Sá, Ana Cravo   +4 more
core  

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Patterns of metastasis in colon and rectal cancer

Scientific Reports, 2016
Investigating epidemiology of metastatic colon and rectal cancer is challenging, because cancer registries seldom record metastatic sites. We used a population based approach to assess metastatic spread in colon and rectal cancers.
M. Riihimäki, A. Hemminki, J. Sundquist, K. Hemminki   +3 more
semanticscholar   +1 more source