Results 111 to 120 of about 5,139,728 (295)

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, EarlyView.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source

Changing outcomes following pelvic exenteration for locally advanced and recurrent rectal cancer

BJS Open, 2019
Pelvic exenteration for locally advanced rectal cancer (LARC) and locally recurrent rectal cancer (LRRC) is technically challenging but increasingly performed in specialist centres. The aim of this study was to compare outcomes of exenteration over time.
M. E. A. G. J. N. Abdul M. W. A. K. K. R. M. G. B. K. Kelly Aalbers Aziz Abraham‐Nordling Alberda Antoni, M. Kelly, A. Aalbers, N. A. Aziz, M. Abraham-Nordling, W. Alberda, A. Antoniou, K. Austin, R. Baker, M. Bali, G. Baseckas, B. Bednarski, G. Beets, P. Berg, J. Beynon, S. Biondo, L. Bordeianou, M. Brunner, P. Buchwald, J. Burger, D. Burling, N. Campain, K. Chan, G. Chang, M. Chew, P. Chong, H. Christensen, M. Codd, A. Colquhoun, A. Corr, M. Coscia, P. Coyne, B. Creavin, L. Damjanović, I. Daniels, M. Davies, R. Davies, J. de Wilt, Q. Denost, C. Deutsch, D. Dietz, E. Dozois, M. Duff, T. Eglinton, M. Evans, M. Evans, N. Fearnhead, F. Frizelle, E. García-Granero, J. L. García-Sabrido, L. Gentilini, M. George, R. Glynn, T. Golda, B. Griffiths, J. Hagemans, D. Harji, D. Harris, A. Heriot, W. Hohenberger, T. Holm, J. Jenkins, Y. Kanemitsu, S. Kapur, D. Keller, S. Kelley, H. Kim, C. Koh, N. Kok, R. Kokelaar, C. Kontovounisios, M. Kusters, D. Larson, S. Laurberg, W. Law, P. Lee, M. Lydrup, A. Lynch, A. Martling, K. Mathis, W. Meijerink, A. Mentha, S. Merkel, F. McDermott, J. McGrath, A. Mihailo, A. Mirnezami, J. Morton, T. Mullaney, M. Nielsen, G. Nieuwenhuijzen, P. Nilsson, P. O'Connell, G. Palmer, D. Patsouras, G. Pellino, G. Poggioli, M. Quinn, A. Quyn, R. Radwan, S. Rasheed, P. Rasmussen, R. Rocha, J. Rothbarth, C. Roxburgh, H. Rutten, É. Ryan, P. Sagar, T. Sammour, A. Schizas, E. Schwarzkopf, V. Scripcariu, I. Shaikh, D. Shida, A. Simpson, N. Smart, J. Smith, M. Solomon, M. M. Sørensen, S. Steele, D. Steffens, L. Stocchi, N. Stylianides, C. Taylor, P. Tekkis, S. Tsukamoto, W. H. Turner, J. Tuynman, G. V. van Ramshorst, D. V. van Zoggel, W. Vasquez-Jiménez, C. Verhoef, M. Verstegen, C. Wakeman, S. Warrier, H. Wasmuth, M. Weiser, J. Wheeler, J. Wild, D. Winter, J. Yip   +140 more
semanticscholar   +1 more source

Cáncer hereditario: fundamentos genéticos [PDF]

, 2005
Genetic counseling plays a key role in the BRCA1/BRCA2 and hMLH1/hMSH2/hMSH6 testing process. The initial genetic counselling encounter will determine the appropriateness of the test by collecting a detailed family history and determining the likelihood ...
Caldés, Trinidad
core   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

New Pattern of Rectal Cancer Treatment: Total Neoadjuvant Therapy

Zhongliu Fangzhi Yanjiu, 2018
Total neoadjuvant therapy (TNT) transfers postoperative adjuvant chemotherapy for rectal cancer to preoperative surgery. Preoperative neoadjuvant chemotherapy followed by concurrent chemoradiotherapy is designed to improve patient compliance and long ...
SUN Peiyan, WU Gang, SUN Peichun
doaj   +1 more source

Rectosigmoid Cancer-Rectal Cancer or Sigmoid Cancer? [PDF]

Am J Clin Oncol, 2022
Hui C, Baclay R, Liu K, Sandhu N, Loo P, von Eyben R, Chen C, Sheth V, Vitzthum L, Chang D, Pollom E.   +10 more
europepmc   +1 more source

Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer

Cancer Science, 2019
Recurrence and chemoresistance in colorectal cancer remain important issues for patients treated with conventional therapeutics. Metformin and phenformin, previously used in the treatment of diabetes, have been shown to have anticancer effects in various
Ji-Hye Park, Young-Heon Kim, E. H. Park, Sun-Joo Lee, Hyewon Kim, A. Kim, Seung Bum Lee, Sehwan Shim, H. Jang, J. Myung, Sunhoo Park, Su-Jae Lee, M. J. Kim   +12 more
semanticscholar   +1 more source

La endometriosis: una enfermedad que sigue siendo enigmática [PDF]

, 2012
La endometriosis es una enfermedad de la mujer, y por tanto, una patología ginecológica, con frecuencia calificada de enigmática y que se define por la presencia de un tejido idéntico o muy semejante a la mucosa endometrial del útero, pero localizado en ...
Acien Álvare, Pedro
core  

Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors

Advanced Science, EarlyView.
A biodegradable molecularly imprinted polymer porous silica sensor enables dual optical readout of doxorubicin via fluorescence and effective optical thickness shifts. The combined transduction mechanisms provide enhanced reliability and quantitative accuracy over clinically relevant concentrations, representing a step toward transient implantable ...
Martina Corsi, Tiziano Di Giulio, Eleonora Vandini, Muhammad Ibrar Asif, Eleonora Daini, Antonietta Vilella, Giuseppina Leo, Alessandra Ottani, Cosimino Malitesta, Daniela Giuliani, Elisabetta Mazzotta, Giuseppe Barillaro   +11 more
wiley   +1 more source

Preliminary study of indocyanine green-guided laparoscopic lateral lymph node dissection for rectal cancer.

PLoS ONE
BackgroundLLNM can occur in mid-low rectal cancer, but LLND in patients with rectal cancer presents certain challenges. Recent years have seen the progressive application of ICG fluorescence imaging technology in colorectal surgery.
Chu-Ying Wu, Wen-Jin Zhong, Kai Ye
doaj   +1 more source