Results 201 to 210 of about 5,139,728 (295)

Clinical characteristics and outcomes in patients with early-onset locally advanced rectal cancer. [PDF]

Ther Adv Med Oncol
Pretta A, Giampieri R, Ziranu P, Bottelli A, Donisi C, Tiberi E, Cimbro E, Randon G, Fraschini M, Spanu D, Didaci L, Dell'Utri V, Pretta G, Mariani S, Puzzoni M, Pusceddu V, Berardi R, Pietrantonio F, Faa G, Scartozzi M.   +19 more
europepmc   +1 more source

The impact of time‐to‐recurrence on post‐recurrence mortality in stage I–III colorectal cancer: A nationwide Danish cohort study

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) recurrence is a significant threat to survival despite surgery with curative intent. The characteristics of CRC recurrence, however, remain poorly understood, challenging postoperative surveillance. This study investigated post‐recurrence mortality and associations between time‐to‐recurrence and mortality among stage
Jesper Nors, Kåre Andersson Gotschalck, Rune Erichsen, Claus Lindbjerg Andersen   +3 more
wiley   +1 more source

Detection of MSI signals from peripheral blood for monitoring response to immune checkpoint blockade therapy in patients with advanced microsatellite‐unstable gastrointestinal cancers: A pilot study

International Journal of Cancer, EarlyView.
What's New? A substantial proportion of patients with microsatellite‐unstable gastrointestinal adenocarcinomas do not benefit from immunotherapy. This study demonstrates that microsatellite instability can be reliably detected in plasma‐derived extracellular vesicle DNA from patients with microsatellite‐unstable gastrointestinal cancers.
Aysel Ahadova, Lena Bohaumilitzky, Thomas Walle, Joscha A. Kraske, Mirjam Tariverdian, Ulrike Ganserer‐Schmitt, Ingrid Hausser‐Siller, Vera Fuchs, Nina Nelius, Gizem Mehtap Erisen, Johannes Gebert, Albrecht Stenzinger, Dirk Jäger, Magnus von Knebel Doeberitz, Georg Martin Haag, Elena Busch, Matthias Kloor   +16 more
wiley   +1 more source

Anastomotic leakage increases the risk of major low anterior resection syndrome 3 years after rectal cancer surgery. [PDF]

Colorectal Dis
Gerdin A, Häggström J, Park J, Lydrup ML, Matthiessen P, Jutesten H, Sandberg S, Angenete E, Rutegård M.   +8 more
europepmc   +1 more source

Oxaliplatin‐induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose–response relationship and impact on quality of life

International Journal of Cancer, EarlyView.
What's New? Oxaliplatin serves a key role in the treatment of rectal cancer, though it is a significant cause of chemotherapy‐induced peripheral neuropathy. As total neoadjuvant therapy, in which all therapy is given before surgery, has become more common, understanding neuropathy has grown increasingly important. This study examined neuropathy and its
Georg W. Wurschi, Andreas Hinz, Melanie Schneider, Jan‐Niklas Becker, Bernd Frerker, Samuel M. Vorbach, Felix Ehret, Markus Diefenhardt, Fabian Schunn, Maria‐Elena von Gruben, Marcel Büttner, Elgin Hoffmann, Alexander Rühle, Josephine Beier, Simone Ferdinandus, Maike Trommer, Ezgi Ceren Sahin, Julian Hlouschek, Kynann Aninditha, Daphne Schepers von Ohlen, Justus Kaufmann, Alina Depardon, Hai Minh Ha, Christopher Kessler, Adrianna Cieslak, Simon Trommer, Alexander Fabian, Florian Rißner, Maximilian Römer, Klaus Pietschmann   +29 more
wiley   +1 more source

Shared decision-making in radiotherapy for rectal cancer - A systematic review. [PDF]

Tech Innov Patient Support Radiat Oncol
Schou LK, Kristensen AW, Steffensen JH, Guren MG, Poulsen LØ, Spindler KG, Skovhus Kronborg CJ.   +6 more
europepmc   +1 more source

Targeting DGKα/PA axis inhibits tumor immune evasion and augments sensitivity to immunotherapy in gastrointestinal cancers

iMeta, EarlyView.
Immune checkpoint inhibitors (ICIs) have shown promising antitumor efficacy in certain types of solid tumors. However, the efficacy of ICIs remains unsatisfactory owing to the dysregulation of signaling pathways in local tumor tissues. Here, we reveal that diacylglycerol kinase α (DGKα)‐derived phosphatidic acid (PA) directly binds to nuclear factor‐κB
Jie Chen, Siqi Liu, Ting Peng, Fenglong Wang, Yuheng Zhu, Jingyuan Pang, Qingnan Wu, Yan Wang, Qimin Zhan   +8 more
wiley   +1 more source

Microsimulation model to identify suboptimal recurrence detection in patients with colorectal cancer following the current standard of care. [PDF]

BMJ Open
Samur S, Gursel E, Gu NY, Carter GC, Sahinkoc M, Ayer T, Chhatwal J, Subramaniam S, Palomares M, Parikh AR, Neugut AI.   +10 more
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Prognostic significance of lymph node-related indices and a novel nomogram for rectal cancer patients with synchronous liver metastases after the preoperative chemoradiotherapy: a population-based study. [PDF]

Transl Cancer Res
Xi K, Wu Y, Sun X, Du C, Wang F, Liu J, Yin Y, Wang Y, Liu J, Li G.   +9 more
europepmc   +1 more source