Results 31 to 40 of about 146,764 (292)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Immunological Landscape and Clinical Management of Rectal Cancer

Frontiers in Immunology, 2016
The clinical management of rectal cancer and colon cancer differs due to increased local relapses in rectal cancer. However, the current molecular classification does not differentiate rectal cancer and colon cancer as two different entities.
Elísabeth ePérez-Ruiz, Pedro eBerraondo   +1 more
doaj   +1 more source

Análisis de la posible influencia de las lesiones sincrónicas en el pronóstico del cáncer colorrectal resecado [PDF]

, 2008
Aim: To analyze the relationship between synchronous lesions in patients with colorectal cancer and their prognostic value. Patients and methods: We have retrospectively reviewed 369 patients with resected colorectal cancer.
Betes, M.T. (María Teresa), Borda-Celaya, F. (F.), Borda-Martin, A. (Ana), Martinez-Peñuela, J.M. (J.M.), Muñoz-Navas, M. (Miguel), Prieto-Martinez, C. (C.)   +5 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Retrospective evaluation of the impact of dose escalation using pre-operative simultaneous integrated boost volumetric modulated arc therapy on the outcome of locally advanced rectal cáncer patients [PDF]

, 2022
Ahmed Elashwah, Abdullah Alsuhaibani, Alaa Abduljabbar, Nasser Al‐Sanea, Samar Alhomoud, Luai H. Ashari, Shouki Bazarbashi, Ali Aljubran, Ahmad Alzahrani, Ahmed K. Awad, Hadeel Almanea, hussah Alhussini, Mohammed Alshabanah   +12 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Tissue-associated bacterial alterations in rectal carcinoma patients revealed by 16S rRNA community profiling

Frontiers in Cellular and Infection Microbiology, 2016
Sporadic and inflammatory forms of colorectal cancer (CRC) account for more than 80% of cases. Recent publications have shown mechanistic evidence for the involvement of gut bacteria in the development of both CRC-forms.
Andrew Maltez Thomas, Andrew Maltez Thomas, Andrew Maltez Thomas, Eliane Camargo de Jesus, Eliane Camargo de Jesus, Ademar Lopes, Samuel Aguiar Junior, Maria Dirlei Begnami, Rafael Malagoli Rocha, Paola Avelar Carpinetti, Anamaria Aranha Camargo, Christian Hoffmann, Helano Carioca Freitas, Helano Carioca Freitas, Israel Tojal da Silva, Diana Noronha Nunes, Joao Carlos Setubal, Joao Carlos Setubal, Emmanuel Dias-Neto, Emmanuel Dias-Neto   +19 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling

Journal of Immunology Research, 2021
Background. Preoperative chemoradiotherapy (pCRT) is a common and essential therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor response and therapeutic resistance to chemoradiotherapy have appeared usually among ...
Hao Liu, Zhenzhan Zhang, Peilin Zhen, Meijuan Zhou   +3 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source