Results 31 to 40 of about 142,029 (216)

Metformin is a metabolic modulator and radiosensitiser in rectal cancer

Frontiers in Oncology, 2023
Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer. Increasing evidence supports a role for altered energy metabolism in the resistance of tumours to anti-cancer therapy, suggesting that targeting ...
Croí E. Buckley, Croí E. Buckley, Rebecca M. O’Brien, Rebecca M. O’Brien, Timothy S. Nugent, Timothy S. Nugent, Timothy S. Nugent, Noel E. Donlon, Noel E. Donlon, Noel E. Donlon, Noel E. Donlon, Fiona O’Connell, Fiona O’Connell, John V. Reynolds, John V. Reynolds, Adnan Hafeez, Diarmuid S. O’Ríordáin, Robert A. Hannon, Paul Neary, Reza Kalbassi, Brian J. Mehigan, Brian J. Mehigan, Paul H. McCormick, Paul H. McCormick, Cara Dunne, Cara Dunne, Michael E. Kelly, Michael E. Kelly, John O. Larkin, John O. Larkin, Jacintha O’Sullivan, Jacintha O’Sullivan, Niamh Lynam-Lennon, Niamh Lynam-Lennon   +33 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

TCF7 transcriptional activation of MACC1 regulates aerobic glycolysis and promotes oxaliplatin resistance in rectal cancer [PDF]

Zhongguo aizheng zazhi
Background and purpose: Rectal cancer occurs on the inner wall of the rectum, and metastasis-associated in colon cancer 1 (MACC1) can promote drug resistance in colon cancer cells.
YAN Yan, ZHOU Liqing, XIA Jianhong, MA Tingting
doaj   +3 more sources

Manejo del cáncer de recto durante el embarazo

Revista Chilena de Obstetricia y Ginecología, 2011
El cáncer de recto tiene baja incidencia en la mujer embarazada, su diagnóstico durante el embarazo suele ser tardío, pues sus síntomas son similares a los propios de la gestación.
Angie Vergara R, Oscar Nariño R, Sergio Carvajal C, Jorge Carvajal C   +3 more
doaj  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Tecnología y globalización en el pronóstico de pacientes con cáncer rectal

Revista Cubana de Medicina Militar, 2019
Desde el siglo XX hasta la fecha, el proceso de globalización ha caracterizado el desarrollo de la economía mundial. En este contexto los países desarrollados son los que tienen directamente el manejo y dominio tecnológico, mientras que los ...
Misdrialis Martínez Romero, Pablo Miguel Raventós Vaquer, Ludmila Martínez Leyva, Tatiana Amable Díaz, Eduardo Carlos Veitía Wilson, Ignacio Morales Martínez   +5 more
doaj  

Constructing a personalized nomogram model for predicting anastomotic leakage after laparoscopic radical resection of rectal cancer

Journal of Radiation Research and Applied Sciences
The purpose of this study was to explore the risk factors for anastomotic leakage (AL) after laparoscopic radical resection of rectal cancer and to construct a nomogram prediction model for AL after laparoscopic radical resection of rectal cancer.
Caigui Liu, Shikang Xu, Yunxiang Zhu, Xiuxiu Cai   +3 more
doaj   +1 more source

A Population-Based Study of Secondary Prostate Cancer Risk after Radiotherapy in Male Patients with Rectal Cancer: A Retrospective Cohort Study

Medicina, 2019
Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patients ...
Jen-Pin Chuang, Yen-Chien Lee, Jenq-Chang Lee, Chin-Li Lu, Chung-Yi Li   +4 more
doaj   +1 more source

High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling

Journal of Immunology Research, 2021
Background. Preoperative chemoradiotherapy (pCRT) is a common and essential therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor response and therapeutic resistance to chemoradiotherapy have appeared usually among ...
Hao Liu, Zhenzhan Zhang, Peilin Zhen, Meijuan Zhou   +3 more
doaj   +1 more source