Results 21 to 30 of about 225,356 (198)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Alterações nas características químicas de um argissolo acinzentado decorrente da aplicação de compostos orgânicos. [PDF]
, 2016 Práticas de manejo do solo afetam as suas propriedades e como a fertilidade dos solos depende da quantidade e qualidade da sua matéria orgânica, é muito provável que mudanças causadas pelas práticas de manejo afetem diretamente a fertilidade dos mesmos ...
CUNHA, T. J. F. +4 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Indicadores químicos de um latossolo vermelho-amarelo em áreas sob macaúba ou pastagem no centro Maranhense. [PDF]
, 2011 A macaúba surge como uma alternativa para a produção de biodiesel e, consorciada com pastagem, ajuda na recuperação de áreas degradadas, devido ao aporte de resíduos no solo, aumentando assim a vida útil das pastagens e minimizando os impactos da ...
ARAÚJO, E. C. E. +5 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Solo cultivado com adubos verdes perenes consorciados com a bananeira, em um agroecossistema sob manejo ecológico em Mato Grosso do Sul: efeito sobre atributos químicos. [PDF]
, 2012 bitstream/item/69056/1/094-carneiro-solo.pdfPublicado também no Cadernos de Agroecologia, v.
BOSQUETTI, L. de B. +6 more
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source