Results 61 to 70 of about 237,005 (239)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Distribuição de cátions de Ce3+ e Er3+ na estrutura cristalina do composto Y3Fe5O12 e seu efeito sobre as propriedades estruturais, óticas e magnéticas [PDF]
, 2023 Neste trabalho, estudamos o efeito da distribuição de cátions sobre as propriedades estruturais, ópticas e magnéticas do composto Y3-xCexFe5-yEryO12 (0,00 ≤ x ≤ 0,02) e (0,00 ≤ y ≤ 0,06) sintetizado pelo método sol gel.
FERREIRA, Mirelly Gonçalves
core
Selective adsorption of ions in charged slit-systems
Condensed Matter Physics, 2013 We study the selective adsorption of various cations into a layered slit system using grand canonical Monte Carlo simulations. The slit system is formed by a series of negatively charged membranes.
M.Valiskó, D. Henderson, D. Boda
doaj +1 more source
The aluminoarsenate Na1.67K1.33Al3(AsO4)4
Acta Crystallographica Section E, 2014 The title compound, sodium potassium trialuminium tetrakis(orthoarsenate), was prepared by solid-state reactions. The anionic framework consists of corrugated layers parallel to (010) and is made up of corner-sharing AlO6 octahedra (site symmetries .2 ...
Mohamad Alem Bouhassine, Habib Boughzala
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Investigation of the Removal of Interfering Iron and Magnesium Ions from Industrial Phosphoric Acid Using Different Surface Adsorbents [PDF]
Iranian Journal of Chemistry & Chemical EngineeringAmong the various methods employed to purify Industrial Phosphoric Acid (IPA), the adsorption method has received considerable attention in both research and industrial settings.
Nahid Khandan +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Scientia Agricola, 2001 O uso agrícola do composto de lixo, como fertilizante orgânico, além de melhorar as propriedades do solo, representa uma alternativa importante para gestão de resíduos sólidos domiciliares.
Cassio Hamilton Abreu Jr. +2 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source