Results 161 to 170 of about 3,585,369 (296)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

INTERVENÇÕES UTILIZADAS NA PROMOÇÃO DE ESTRATÉGIAS DE COPING NA DEPRESSÃO EM MULHERES COM CÂNCER INTERVENCIONES UTILIZADAS PARA PROMOVER ESTRATEGIAS DE COPING PARA LA DEPRESIÓN ENTRE MUJERES CON CÁNCER APPLIED INTERVENTIONS TO PROMOTE COPING STRATEGIES FOR DEPRESSION AMONG WOMEN WITH CANCER

Ciencia y Enfermería, 2009
A depressão tem sido observada em portadores de doenças crônico-degenerativas, incluindo câncer. A utilização de diferentes estratégias de coping nessas condições patológicas pode ser extremamente importante, em face da presença de fatores estressores e ...
LUCIMARA MORELI, JEANNE MARIE R STACCIARINI, ARIANE DE FREITAS CARDOSO, EMILIA CAMPOS DE CARVALHO   +3 more
doaj  

Atendimentos a Crianças e Adolescentes com Câncer em Minas Gerais: Retrato de uma Década

, 2019
Murilo César do Nascimento
openalex   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

EFEITOS DA ALTERNAGINA-C OBTIDA DA PEÇONHA DE BOTHROPS ALTERNATUS EM LINHAGENS DE CÉLULAS DE CÂNCER DE MAMA TRIPLO NEGATIVO

, 2022
Hélder Silva e Luna, FELIPE DOS REIS TENÓRIO NUNES, JOÃO PAULO BEZERRA CIRILO   +2 more
openalex   +1 more source

Pílula do câncer na TV brasileira: a cobertura de programas televisivos sobre uma controvérsia científica [PDF]

, 2021
Marina Ramalho, Marcela Vitor Alvaro, Vanessa Brasil de Carvalho   +2 more
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Otimismo e Suporte Social em Mulheres com Câncer de Mama: Uma Revisão Sistemática

, 2016
Micheline Roat Bastianello, Cláudio Simon Hutz   +1 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source