Results 31 to 40 of about 343,264 (217)

Cervical cancer screening among HIV-positive women in urban Uganda: a cross sectional study

BMC Women's Health, 2022
Background Women living with Human Immunodeficiency Virus (HIV) are at a high risk for early development of cervical cancer. Adherence to cervical cancer prevention strategies in this population is vital for the early detection and treatment of cervical ...
Najjuka Sarah Maria, Connie Olwit, Mark Mohan Kaggwa, Rose Chalo Nabirye, Tom Denis Ngabirano   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Estudo de infecções por papilomavírus humanos em pacientes do sexo feminino, detectados pela técnica de captura do híbrido

DST, 2002
Introdução: Apesar de todos os esforços, a epidemia de papilomavírus humano (HPV) continua crescendo. Por esta razão, a busca de novas ferramentas de diagnóstico para as infecções causadas por estes vírus se faz necessária.
Fernanda N Carestiato, Maria Odete O. Carvalho, Mariza O Ribeiro, Mareia Marinho, Fábio M. Barbosa, Licinio E. Silva, Trude Dimetz, Ledy H.S. Oliveira, Silvia M.B. Cavalcanti   +8 more
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The Effect of Cervical Cancer Counseling on Cervical Cancer Prevention Behavior in Women of Childbearing Age: A Literature Study

Jurnal Kedokteran Diponegoro, 2023
Background: : According to World Health Organization (WHO) data, cervical cancer is the second leading cause of death worldwide . In 2020 the worldwide burden of cervical cancer is significant, there are an estimated 604,000 new infections and 342,000 ...
Miranti Puteri Aulia, Monica Dwi Hartanti   +1 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Chinese Expert Consensus on Application of HPV Vaccine in Perioperative Treatment of High-Grade Cervical Intraepithelial Neoplasia (2025 Edition)

Zhongliu Fangzhi Yanjiu
In women with high-grade squamous intraepithelial lesion (HSIL) undergoing excision therapy, vaccination with human papillomavirus (HPV) vaccine may reduce the risk of postoperative recurrence.
Cervical Cancer Prevention and Control Research Professional Committee of Chinese Association for Maternal and Child Health Study
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prevenção do câncer cervical

DST, 2010
Introdução: o câncer do colo uterino é conhecido como uma das causas mais frequentes de óbito na população feminina em todo o mundo. A infecção persistente por papilomavírus humano (HPV) é o principal fator de risco para o câncer cervical e suas lesões ...
Márcia Elena Z. Bringhenti, Ticiana G. Dozza, Toni Ricardo Martins, Maria Luiza Bazzo   +3 more
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