Results 141 to 150 of about 10,776,501 (260)

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan   +12 more
wiley   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

open access: yesAdvanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva   +18 more
wiley   +1 more source

Combined Immune‐Peptide Nanofiber with HSP70/AKT/mTOR Axis Blockade Enhances Photothermal Immunotherapy, Inhibiting Tumor Growth and Recurrence

open access: yesAdvanced Science, EarlyView.
A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang   +11 more
wiley   +1 more source

CÂNCER DE MAMA: A POSSIBILIDADE DA DETECÇÃO PRECOCE

open access: yesRevista Uningá, 2014
Os elevados índices de incidência e mortalidade por câncer de mama no Brasil justificam a implementação de ações nacionais voltadas para a prevenção e o controle do câncer.
HENRIQUE O. LAUER BARTH   +1 more
doaj  

GINCANA ROSA: ESTRATÉGIA PARA A PREVENÇÃO DO CÂNCER DE MAMA

open access: yes, 2020
Introdução: O câncer de mama é uma das principais neoplasias que atingem a população feminina, sendo fundamental o desenvolvimento de estratégias de prevenção.
UFPE   +3 more
core  

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

open access: yesAdvanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng   +8 more
wiley   +1 more source

O conhecimento e a prática de mamografia em mulheres residentes em Florianópolis/SC: estudos de base populacional [PDF]

open access: yes, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2013O objetivo deste trabalho é descrever o conhecimento e a prática de mamografia e identificar os ...
Schneider, Ione Jayce Ceola
core  

Patient‐Personalized Membrane‐Coated Magnetic Nanovectors: Probing the Biomimetic Interface for Targeted Tumor Theranostics

open access: yesAdvanced NanoBiomed Research, EarlyView.
This study presents a label‐free spectroscopic platform to evaluate membrane protein conformation on patient‐derived glioblastoma cell membrane‐coated magnetic nanovectors. This work demonstrates that preserving membrane protein integrity during nanoparticle fabrication enhances homotypic tumor targeting and reduces hard protein corona formation ...
Daniele De Pasquale   +16 more
wiley   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

open access: yesAngewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt   +9 more
wiley   +1 more source

Câncer de mama: da descoberta à recorrência da doença

open access: yesRevista Eletrônica de Enfermagem, 2007
Estudo exploratório e descritivo que objetivou compreender o sentimento da mulher mastectomizada desde o diagnóstico até a possibilidade da recorrência do câncer de mama, desenvolvido com 15 mulheres com as idades compreendidas entre 30 a 75 anos ...
Luana de Sousa Pinho   +3 more
doaj  

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