Results 131 to 140 of about 39,920 (269)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Proposta de modelo de arame (hook-wire) para marcar lesões mamárias não palpáveis [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências Médicas.Introdução: O presente trabalho consiste na proposição de um novo arame de marcação para guiar biópsias cirúrgicas
Ghizzo, Affonso Celso
core  

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

ANÁLISE ESPACIAL DA MORTALIDADE DO CÂNCER DE MAMA E COLO DE ÚTERO NO BRASIL EM 2004

Revista de Pesquisa Cuidado é Fundamental Online, 2009
No Brasil, o câncer de mama e do colo uterino tornou-se um grande problema de saúde pública em decorrência do elevado número de óbitos. Objetivo: Analisar a distribuição de óbitos por câncer de mama e colo uterino no Brasil. Métodos: Estudo descritivo de
Raíla Souza Santos, Ana Luiza Barreto Zapponi, Enirtes Caetano Prates Melo   +2 more
doaj   +4 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

New Cardiovascular Biomarkers in Breast Cancer Patients Undergoing Doxorubicin-Based Chemotherapy. [PDF]

Arq Bras Cardiol, 2023
Pestana RMC, Silvino JPP, Oliveira AN, Soares CE, Sabino AP, Simões R, Gomes KB.   +6 more
europepmc   +1 more source

Sustainable Microwave‐Enhanced Synthesis of 2‐Substituted Benzofurans From o‐Alkynylanisoles in Acidic Deep Eutectic Solvents

European Journal of Organic Chemistry, EarlyView.
A microwave‐enhanced sustainable and versatile approach to substituted benzofurans from 2‐alkynylanisoles enabled by an active Brønsted acidic deep eutectic solvent. The research on alternative media for organic transformations remains a highly demanding topic.
Alessandra Gritti, Angelica Sita, Mehri Goudarzi, Stefano Fedeli, Elison Lepore, Donatella Nava, Matteo Tiecco, Alessandro Caselli, Valentina Pirovano, Giorgio Abbiati   +9 more
wiley   +1 more source

[Construction and validation of a video about breast cancer for deaf womenConstrucción y validación de un video sobre el cáncer de mama para mujeres sordas]. [PDF]

Rev Cuid, 2023
Pereira-Gomes JD, Tomaz-De-Carvalho A, Sousa-Albuquerque-Brandao MG, Galindo-Neto NM, Do-Livramento-Fortes-Figueiredo M, Ribeiro Mariano-Grimaldi M.   +5 more
europepmc   +1 more source

Saúde da mulher: questões da prática assistencial para enfermagem [PDF]

, 2013
Explora-se o processo de trabalho do profissional da enfermagem, dentro do Programa de Assistência Integral à Saúde da Mulher, perpassando por temáticas sobre a saúde sexual e reprodutiva, o acompanhamento pré-natal, a humanização das ações em saúde da ...
Costa, Dayana Dourado de Oliveira, Fernandes, Ana Carolina Uruçu Rego, Silva, Mayara Pereira da, Universidade Federal do Maranhão - UNA-SUS/UFMA   +3 more
core  

Strategic construction of fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents for amplifying cancer phototheranostics

FlexMat, EarlyView.
The development of conventional phototheranostic nanomedicines suffers from an intrinsic trade‐off between NIR‐II fluorescence emission and phototherapeutic effects, leading to poor overall efficacy. Herein, we propose an innovative fluorination strategy by constructing fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents to ...
Xiaoming Hu, Achen Qin, Caijun Zhu, Jinshuo Mi, Zejing Chen, Jiaying Shao, Zhen Li, Zhen Yang   +7 more
wiley   +1 more source