Results 221 to 230 of about 14,173 (271)

Spatial Transcriptomics and Bulk RNA‐Seq Analysis Revealed Molecular Classification of Invasive Lobular Carcinoma

open access: yesCancer Science, EarlyView.
Spatial transcriptomics and bulk RNA‐seq data analysis revealed the molecular characteristics of invasive lobular carcinoma (ILC). ILC was classified into three clusters: proliferative, immunoreactive, and stromal‐rich, with different prognoses. ABSTRACT Invasive lobular carcinoma (ILC) is a special type of breast cancer.
Momoko Tokura   +9 more
wiley   +1 more source

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

open access: yesCancer Science, EarlyView.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu   +10 more
wiley   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

open access: yesCancer Science, EarlyView.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang   +7 more
wiley   +1 more source

Children of Divorced Parents—The Limitations of One‐Size‐Fits‐All Interventions

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT The political agenda of the Danish School Reform in 2014 provides a heightened awareness of pupils' mental health–including children of divorced parents. The primary focus is to support children's emotion management, and in that regard, conversation groups are offered to children experiencing divorce.
Pernelle Rose Hansen
wiley   +1 more source

Breast cancer in northern Peru: molecular subtypes and HER2 low. [PDF]

open access: yesRev Peru Med Exp Salud Publica
Gómez-Rázuri K   +3 more
europepmc   +1 more source

A Case Study Exploring Opportunities to Strengthen Supportive School Systems for Expectant and Parenting Adolescents

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT In 2021, Maryland Bill HB0401—Pregnant and Parenting Students Policies and Reports was passed, requiring school districts to create policies around excused absences, childcare and wraparound services for expectant and parenting youth. Despite existing policies, there are often inconsistencies in how expectant and parenting youth (EPY) are ...
Asari Offiong, Emily Young
wiley   +1 more source

Exploring How Affordances of Play Materials Shape Chinese Parents' Interaction With Children: Media‐Elicited Focus Group Discussion

open access: yesChildren &Society, EarlyView.
ABSTRACT Existing literature on children's play materials predominantly reflects theoretical frameworks and empirical data generated in the Global North, where ideas of “developmental appropriateness” often overlook the socio‐cultural specificity of materials' affordances and parental expectations.
Zhiyu Zhang, Jingyun Zhang
wiley   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

open access: yesCell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li   +6 more
wiley   +1 more source

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