Results 61 to 70 of about 1,168,282 (300)
International Journal of Molecular Sciences, 2019 Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels. Primary BAs play critical roles in cholesterol
Huawei Zeng +4 more
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Revista Derecho del Estado, 2021 Para la teoría constitucional hay dos preguntas claves que surgen en cualquier discusión acerca de la creación de nuevas constituciones. Primero, ¿qué mecanismo debe utilizarse para el ejercicio del poder constituyente?
Joel Colón-Ríos
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Acta Cirúrgica Brasileira, 2002 OBJETIVO: Estudar os efeitos da colostomia proximal terminal na cicatrização de anastomoses colo-cólicas em ratos. MÉTODOS: 36 ratas foram divididas em 2 grupos: grupo controle (C) com 12 animais submetidos à ressecção cólica segmentar seguida de ...
Leme Marcelo Betim Paes +3 more
doaj
Peritoneal fluid changes in horses subjected to small colon distension
Pesquisa Veterinária Brasileira, 2011 Intestinal devitalization in cases of small colon obstruction may be difficult to detect based only in clinical signs. The purpose was to serially evaluate blood and peritoneal fluid of horses subjected to small colon distension.
Rafael R Faleiros +6 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Influência do tempo transcorrido entre a lesão do cólon e a síntese no processo de cicatrização
Acta Cirúrgica Brasileira, 2000 O tratamento das lesões do cólon têm se modificado com relação à escolha da técnica do reparo primário à colostomia e ao reparo secundário. Entre os fatores de risco para síntese primária está o tempo transcorrido.
Maria de Lourdes Pessole Biondo-Simões +8 more
doaj +1 more source
Criticón, 2023 In his epistle of Rerum familiarum libri IV, 1, Petrarca narrates his ascension to Mount Ventoso. He describes various natural elements (such as the mountain, the earth, the sea) and when he reaches te summit he alludes to «nubes erant sub pedibus».
Isabel Colón Calderón
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source