Results 41 to 50 of about 833,458 (232)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A suppository-base-matrix tablet for time-dependent colon-specific delivery system
Brazilian Journal of Pharmaceutical Sciences, 2014 Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms.
Meijuan Zou +6 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Acta Cirúrgica Brasileira, 2002 OBJETIVO: Estudar os efeitos da colostomia proximal terminal na cicatrização de anastomoses colo-cólicas em ratos. MÉTODOS: 36 ratas foram divididas em 2 grupos: grupo controle (C) com 12 animais submetidos à ressecção cólica segmentar seguida de ...
Leme Marcelo Betim Paes +3 more
doaj
Creating a Patient-Centric, Global, Decentralized Health System
Blockchain in Healthcare Today, 2018 Session Description: Over the past decade, there have been many innovations in new payment and care delivery models and technology – from telemedicine to AI to blockchain. These innovations, however, need to be used in tandem to drive real change.
Kenneth Colon
doaj +2 more sources
Peritoneal fluid changes in horses subjected to small colon distension
Pesquisa Veterinária Brasileira, 2011 Intestinal devitalization in cases of small colon obstruction may be difficult to detect based only in clinical signs. The purpose was to serially evaluate blood and peritoneal fluid of horses subjected to small colon distension.
Rafael R Faleiros +6 more
doaj +1 more source
Criticón, 2023 In his epistle of Rerum familiarum libri IV, 1, Petrarca narrates his ascension to Mount Ventoso. He describes various natural elements (such as the mountain, the earth, the sea) and when he reaches te summit he alludes to «nubes erant sub pedibus».
Isabel Colón Calderón
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Acta Cirúrgica Brasileira, 2000 As anastomoses colônicas estão associadas à alta incidência de deiscências e o choque é um dos fatores etiológicos relacionados.O objetivo do presente estudo foi correlacionar as alterações do fluxo sanguíneo intestinal decorrentes do choque hipovolêmico
Greca Fernando Hintz +6 more
doaj