Results 81 to 90 of about 1,168,282 (300)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

Science, 2020
So much more to mucus Mammals accommodate a dense community of metabolically active microorganisms in their gut. This is not a passive relationship, and host and microbe have antagonistic as well as mutualistic responses to each other.
Kirk Bergstrom, Kirk Bergstrom, Xindi Shan, D. Casero, Albert Batushansky, V. Lagishetty, Jonathan P. Jacobs, Christopher M Hoover, Y. Kondo, Bojing Shao, Liang Gao, W. Zandberg, Benjamin Noyovitz, J. M. McDaniel, Deanna L. Gibson, S. Pakpour, N. Kazemian, Samuel McGee, C. Houchen, C. Rao, Timothy M. Griffin, Timothy M. Griffin, J. Sonnenburg, R. McEver, R. McEver, J. Braun, Lijun Xia, Lijun Xia   +27 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

El impacto del SAS 82-Consideraciones de fraude en la auditoría de estados financieros- en la práctica de la contabilidad pública de firmas locales y practicantes independientes en Puerto Rico

Fórum Empresarial, 1999
Sinopsis de las siguientes tesis: El impacto del SAS 82-Consideraciones de fraude en la auditoría de estados financieros- en la práctica de la contabilidad pública de firmas locales y practicantes independientes en Puerto Rico, Análisis financiero ...
Glorimar Pérez Colón
doaj   +1 more source

Puerto Rico, Covid-19 y el baile de la corrupción

Question, 2020
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Eliseo Colón Zayas
doaj   +1 more source

Estudo da formação de aderências e da cicatrização de anastomoses colônicas em ratos com sepse peritoneal induzida [PDF]

, 2011
OBJETIVO: Avaliar os efeitos da sepse abdominal sobre a formação de aderências e a cicatrização de anastomoses colônicas em ratos. MÉTODOS: 40 ratos distribuídos em dois grupos contendo 20 animais, para anastomose do cólon esquerdo na presença (grupo S ...
Agalar F, Ahrendt GM, Alexandre Malta Brandão, Aydin C, Bedirli A, Biondo-Simões M LP, Biondo-Simões MLP, Biondo-Simões MLP, Bothin C, Buchs NC, Cahill RA, De Hann BB, De Hingh IH, Fabiana Pirani Carneiro, João Batista de Sousa, Liakakos T, Marcos Vinícius Melo de Oliveira, Nair SK, Naresse LE, Omar Feres, Ozen IO, Rittirsch D, Rocha AA, Rogério Serafim Parra, Silvana Marques e Silva, Teke Z, Vânia Maria Moraes Ferreira, Wang P   +27 more
core   +4 more sources

Somatic Evolution in Non-neoplastic IBD-Affected Colon

Cell, 2020
Summary Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts from 41 non-IBD ...
S. Olafsson, R. McIntyre, Tim H. H. Coorens, T. Butler, Hyunchul Jung, Philip S. Robinson, H. Lee-Six, M. Sanders, K. Arestang, C. Dawson, M. Tripathi, K. Strongili, Y. Hooks, M. Stratton, M. Parkes, I. Martincorena, T. Raine, P. Campbell, C. Anderson   +18 more
semanticscholar   +1 more source