Results 171 to 180 of about 748,226 (258)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A palladium complex of 2,2'-(propane-1,3-diylbis(oxy))dibenzenaminium chloride on SBA-15 as a returnable, environmental and selective nanostructured-catalyst in the Suzuki C-C coupling reaction. [PDF]

RSC Adv
Mohammadi S, Nikoorazm M, Tahmasbi B, Abbasi Tyula Y.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Total Synthesis of <i>iso</i>-Gladiolin Methyl Ester (Lagriene Methyl Ester) via Catalytic Asymmetric C-C Coupling of Alcohols. [PDF]

J Am Chem Soc
Verboom KL, Cho Y, Duncan JA, Zhang Y, Alkhalaf LM, Challis GL, Krische MJ.   +6 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The subsurface Pt-promoted TiO_2-x overlayer enhances succinonitrile production in the photocatalytic C-C coupling of acetonitrile. [PDF]

Natl Sci Rev
Zhou X, Song H, Chen Z, Zhao S, Wang J, Wang Y, Gao X, Lin L, Yao S.   +8 more
europepmc   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Photocatalytic Asymmetric C-C Coupling for CO₂ Reduction on Cu-Zn Bimetallic Catalysts with Dipole-Limiting Effects. [PDF]

Adv Sci (Weinh)
Ma P, Yu Y, Wen F, Guo H, Li B, Deng G, Shi X, Jiang D, Huang R.   +8 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Voltage- and pH-driven evolution of multi-pathway C-C coupling in CO₂ electroreduction on copper. [PDF]

Chem Sci
Zhang C, Wang Z.
europepmc   +1 more source