Results 1 to 10 of about 123,266 (262)

Catalyst-controlled directing group translocation in the site selective C-H functionalization of 3-carboxamide indoles and metallocarbenes. [PDF]

Nat Commun
Complementary methods toward the selective functionalization of indole and oxindole frameworks employing an alternative strategy in heteroaryl C–H functionalizations are presented herein.
Gu K, Hall MT, Tucker ZD, Durling GM, Ashfeld BL.   +4 more
europepmc   +2 more sources

Platinum-Catalyzed C–H Functionalization

Chemical Reviews, 2017
Recent developments in C–H bond activation and functionalization by Pt complexes are surveyed. Topics include the following: fundamental mechanistic investigations of C–H activation; stoichiometric intra- and intermolecular C–H activation; reactions of ...
Jay A Labinger
exaly   +1 more source

Radical Advances in C(sp3)−H Functionalization: Foundations for C–H Cross-Coupling

, 2022
C−H functionalization reactions are playing an increasing role in the preparation and modification of complex organic molecules, including pharmaceuticals, agrochemicals, and polymer precursors.
Dung, Golden, Sung-Eun, Suh, Shannon, Stahl   +2 more
core   +1 more source

Catalytic Intermolecular Functionalization of Benzimidazoles [PDF]

, 2019
This chapter describes contemporary strategies for selective catalytic intermolecular functionalization of the benzimidazole scaffold. Functionalization at nitrogen and position C-2 is well developed employing copper, palladium, rhodium, nickel, and ...
Fjellaksel, Richard, Jørn H. Hansen, Hansen, Jørn H, Richard Fjellaksel   +3 more
core   +1 more source

A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor [PDF]

, 2021
Photoredox catalysis has provided many approaches to C(sp3)-H functionalization that enable selective oxidation and C(sp3)-C bond formation via the intermediacy of a carbon-centered radical. While highly enabling, functionalization of the carbon-centered
Isabelle, Leibler, Abigail, Doyle, Leibler, Isabelle Nathalie-Marie, Tekle-Smith, Makeda A, Doyle, Abigail G, Makeda A., Tekle-Smith   +5 more
core   +1 more source

Arenes and Heteroarenes C–H Functionalization Under Enabling Conditions: Electrochemistry, Photoelectrochemistry & Flow Technology

, 2023
C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species.
Ayesha , Murtaza, Bahareh, Shirinfar, Zia , ulhaq, Guilherme M. , Martins, Samina , Aslam, Nisar, Ahmed, Sadia , Rani   +6 more
core   +1 more source

Green Solvents for C-H Functionalization

, 2023
Organic solvents are ubiquitous in most of the synthetic processes and play a crucial role in influencing the chemical behavior of catalytic system and/or reactive species. Modern chemistry inevitably includes an evaluation of the chemical efficiency and
Rossini, Gabriele, Vaccaro, Luigi, Brufani, Giulia, Santoro, Stefano   +3 more
core   +1 more source

Chiral Transient Directing Groups in Transition-Metal-Catalyzed Enantioselective C–H Bond Functionalization

, 2020
International audienceTransition metal-catalyzed C-H bond functionalization has known a rapid evolution in the last years, offering new strategies for reaching high molecular complexity in a step-and atom-economical way. Despite the indisputable advances,
Sara Mazeh, Tatiana Besset, Mazeh, Sara, Besset, Tatiana, Lapuh, Maria, Maria I. Lapuh   +5 more
core   +1 more source

Isodesmic C–H Functionalization: Carboxyl-Assisted Remote meta- and ortho-C–H Iodination of Arenes via Shuttle Catalysis

, 2021
Isodesmic C–H functionalization reactions are extremely rare. Herein we report the first Pd(II)-catalyzed isodesmic C–H iodination of arenes using 2-nitrophenyl iodides as the mild iodinating reagents.
Lei, Cai, Gang, Li, Xinchao, Wang, Hang, Wang, Xiaoxi, Chen, Chunhui, Zhang, Lei, Fu, Shangda, Li   +7 more
core   +1 more source

Late-stage functionalization of pharmaceuticals, agrochemicals, and natural products

, 2023
Late-stage functionalization has become a method of choice for the rapid generation of chemical libraries. The high selectivity of these transformations provides great leverage for the agrochemical and pharmaceutical industries that rely on the fast ...
Selmi-Higashi, E, Stellios Arseniyadis, François Richard, Richard, F, Elias Selmi‐Higashi, Arseniyadis, S   +5 more
core   +1 more source