Results 31 to 40 of about 123,266 (262)

Radical‐Promoted Distal C‐H Functionalization of C(sp3) Centers with Fluorinated Moieties

, 2020
International audienceDue to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals and materials science.
Tatiana Besset, Thomas Castanheiro, Nobile, Enzo, Castanheiro, Thomas, Besset, Tatiana, Enzo Nobile   +5 more
core   +1 more source

Iron-catalyzed aliphatic C-H functionalization to construct carbon-carbon bonds. [PDF]

Nat Commun
Although cytochrome P450 enzymes are powerful catalysts for hydrogen-atom abstraction from alkanes by iron-oxo species, the process typically leads to oxygenated products due to ultrafast oxygen rebound.
Zhou L, Cai H, Xie D, Sun K, Zhu S, Guo M, Han W.   +6 more
europepmc   +2 more sources

Strategies to transform remote C(sp3)-H bonds of amino acid derivatives

Tetrahedron Chem, 2022
Amino acids and peptides play an important role in nature as well as in the pharmaceutical industry. Therefore, transformation of amino acids and peptides into their unnatural derivatives via step and atom economical ways is highly demanding. Although, a
Supreeta Sen, Jayabrata Das, Debabrata Maiti   +2 more
doaj   +1 more source

Site-Selective A-C-H Functionalization of Trialkylamines via Reversible Hydrogen Atom Transfer Catalysis

, 2021
Trialkylamines are widely found in naturally-occurring alkaloids, synthetic agrochemicals, biological probes, and especially pharmaceuticals agents and pre-clinical candidates.
Franziska, Schoenebeck, Yangyang, Shen, Ignacio, Funes-Ardoiz, Tomislav, Rovis   +3 more
core   +1 more source

Silver-Mediated Direct sp(3) C-H Bond Functionalization

, 2015
Direct sp(3) C-H bond functionalization is an efficient, straightforward, and powerful method to construct new C-X (X = C, N, F, S) bonds from nonfunctionalized aliphatic motif of organic molecules, which has been used in late-stage modification of ...
Zhou, Taigang, Zhang-Jie Shi, Shi, Zhang-Jie, Taigang Zhou   +3 more
core   +1 more source

Electrochemical Benzylic C-H Functionalization with Isocyanides

, 2021
We report the challenging direct carbamoylation or cyanation of benzylic C(sp3)-H bonds with an isocyanide via an electrochemical process giving rise to structures which are encountered in several biologically relevant compounds and drugs.
Guillaume, VINCENT, Laurence, Grimaud, Régis, Guillot, Maxime, Vitale, Shanyu, Tang   +4 more
core   +1 more source

C-H Functionalization via Iron-Catalyzed Carbene-Transfer Reactions

Molecules, 2020
The direct C-H functionalization reaction is one of the most efficient strategies by which to introduce new functional groups into small organic molecules.
Claire Empel, Sripati Jana, Rene M. Koenigs   +2 more
doaj   +1 more source

Catalyst-Controlled C–H Functionalization of Adamantanes Using Selective H‑Atom Transfer

, 2018
A method for the direct functionalization of diamondoids has been developed using photoredox and H atom transfer catalysis. This C–H alkylation reaction has excellent chemoselectivity for the strong 3° C–H bonds of adamantanes in polyfunctional molecules.
Abigail Feceu (5237030), Hai-Bin, Yang, David Martin (6028910), Hai-Bin Yang (1819423), Abigail Feceu (6035636), Hai-Bin Yang, Abigail Feceu, Hai-Bin Yang (6035633), David B. C. Martin (2386141), David, Martin, David B. C. Martin, Abigail, Feceu   +11 more
core   +1 more source

Urea-Catalyzed Functionalization of Unactivated C–H Bonds

, 2020
Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts ...
Benjamin, Wigman, Alex L. Bagdasarian (6075210), Hosea, Nelson, Stasik Popov (6075209), Alex L., Bagdasarian, Benjamin Wigman (6075208), Stasik, Popov, Wenjing, Wei, Hosea Nelson (5860601), woojin lee (8480169), Wenjing Wei (8480141), woojin, lee   +11 more
core   +1 more source

KI-H2O2 promoted intramolecular oxidative CH Functionalization: Synthesis of Benzo[d]thiazol-2-amines

Results in Chemistry, 2022
This work reported a novel, efficient and green technique for the synthesis of N-substituted benzothiazoles using KI/H2O2 in DCM via intramolecular oxidative CH functionalization was carried out.
Manish M. Katiya, Madhuri M. Sontakke, Madhukar G. Dhonde   +2 more
doaj   +1 more source