Electrochemistry-Enabled Ir-Catalyzed Vinylic C−H Functionalization [PDF]
, 2019 Synergistic use of electrochemistry and organometallic catalysis has emerged as a powerful tool for site-selective C–H functionalization, yet this type of transformation has thus far mainly been limited to arene C–H functionalization.
Qi-Liang, Yang +7 more
core +2 more sources
Transition-metal-free electrochemical-induced active C(sp3)-H functionalization
Green Chemistry Letters and Reviews, 2023 Direct C–H bond functionalization is the most effective technique to construct C–X (X = C, N, O, S, etc.), which could simplify the conventional synthesis methods.
Xiaolong Ma +4 more
doaj +1 more source
Strategies to transform remote C(sp3)-H bonds of amino acid derivatives
Tetrahedron Chem, 2022 Amino acids and peptides play an important role in nature as well as in the pharmaceutical industry. Therefore, transformation of amino acids and peptides into their unnatural derivatives via step and atom economical ways is highly demanding. Although, a
Supreeta Sen +2 more
doaj +1 more source
Transition Metal-Catalyzed Functionalization of C−H and C−C Bonds [PDF]
, 2018 In this dissertation, the development of several novel organic synthetic methods featuring the functionalization of C−H and C−C bonds was described by using transition metal catalysis, including the Pd-catalyzed β sp3 C−H sulfonyloxylation of alcohols ...
Xu, Yan
core +1 more source
Site-Selective A-C-H Functionalization of Trialkylamines via Reversible Hydrogen Atom Transfer Catalysis [PDF]
, 2021 Trialkylamines are widely found in naturally-occurring alkaloids, synthetic agrochemicals, biological probes, and especially pharmaceuticals agents and pre-clinical candidates.
Franziska, Schoenebeck +3 more
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A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor [PDF]
, 2021 Photoredox catalysis has provided many approaches to C(sp3)-H functionalization that enable selective oxidation and C(sp3)-C bond formation via the intermediacy of a carbon-centered radical. While highly enabling, functionalization of the carbon-centered
Isabelle, Leibler +8 more
core +3 more sources
Late-stage functionalization of pharmaceuticals, agrochemicals, and natural products
, 2023 Late-stage functionalization has become a method of choice for the rapid generation of chemical libraries. The high selectivity of these transformations provides great leverage for the agrochemical and pharmaceutical industries that rely on the fast ...
Selmi-Higashi, E +5 more
core +1 more source
Urea-Catalyzed Functionalization of Unactivated C–H Bonds [PDF]
, 2020 Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts ...
Benjamin, Wigman +11 more
core +2 more sources
C-H Functionalization via Iron-Catalyzed Carbene-Transfer Reactions
Molecules, 2020 The direct C-H functionalization reaction is one of the most efficient strategies by which to introduce new functional groups into small organic molecules.
Claire Empel +2 more
doaj +1 more source
Radical-Mediated Regiodivergent C(sp3)–H Functionalization of N-Substituted Indolines via Enzymatic Carbene Transfer [PDF]
Indolines are ubiquitous structural motifs found in pharmaceuticals and natural products but modification of these scaffolds via selective C(sp3)–H functionalization represents a major challenge.
Ru, Cui +4 more
core +1 more source