Results 31 to 40 of about 6,068,014 (260)

C-H Functionalization via Iron-Catalyzed Carbene-Transfer Reactions

Molecules, 2020
The direct C-H functionalization reaction is one of the most efficient strategies by which to introduce new functional groups into small organic molecules.
Claire Empel, Sripati Jana, Rene M. Koenigs   +2 more
doaj   +1 more source

KI-H2O2 promoted intramolecular oxidative CH Functionalization: Synthesis of Benzo[d]thiazol-2-amines

Results in Chemistry, 2022
This work reported a novel, efficient and green technique for the synthesis of N-substituted benzothiazoles using KI/H2O2 in DCM via intramolecular oxidative CH functionalization was carried out.
Manish M. Katiya, Madhuri M. Sontakke, Madhukar G. Dhonde   +2 more
doaj   +1 more source

Transition Metal-Catalyzed Remote C–H Bond Functionalization of Cyclic Amines

SynOpen, 2022
C–H bond functionalization is one of the most effective strategies for the rapid synthesis of cyclic amines containing substituents in the ring, which are core structures of many bioactive molecules. It is, however, much more challenging to perform this
Weijie Chen, Xiaoyu Yang, Xi Cao
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Photocatalytic sequential C–H functionalization expediting acetoxymalonylation of imidazo heterocycles

Beilstein Journal of Organic Chemistry, 2023
The importance of functionalized imidazo heterocycles has often been featured in several impactful research both from academia and industry. Herein, we report a direct C-3 acetoxymalonylation of imidazo heterocycles using relay C–H functionalization ...
Deepak Singh, Shyamal Pramanik, Soumitra Maity   +2 more
doaj   +1 more source

Dirhodium tetracarboxylates as catalysts for selective intermolecular C–H functionalization

Nature Reviews Chemistry, 2019
C–H functionalization has become widely recognized as an exciting new strategy for the synthesis of complex molecular targets. Instead of relying on functional groups as the controlling elements of how molecules are assembled, this strategy offers an ...
H. Davies, Kuangbiao Liao
semanticscholar   +1 more source

Imine as a linchpin approach for meta-C–H functionalization

Nature Communications, 2021
Despite the widespread applications of C–H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing groups (DGs) served as ancillary ligands to ensure ortho -, meta - and para -C–H functionalization ...
Sukdev Bag, S. Jana, Sukumar Pradhan, Sumana Bhowmick, Nupur Goswami, Soumya Kumar Sinha, D. Maiti   +6 more
semanticscholar   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source