Urea-Catalyzed Functionalization of Unactivated C–H Bonds [PDF]
, 2020 Herein we report the 3,5bistrifluoromethylphenyl urea-catalyzed functionalization of unactivated C–H bonds. In this system, the urea catalyst mediates the formation of high-energy vinyl carbocations that undergo facile C–H insertion and Friedel–Crafts ...
Benjamin, Wigman +11 more
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Site-Selective A-C-H Functionalization of Trialkylamines via Reversible Hydrogen Atom Transfer Catalysis [PDF]
, 2021 Trialkylamines are widely found in naturally-occurring alkaloids, synthetic agrochemicals, biological probes, and especially pharmaceuticals agents and pre-clinical candidates.
Franziska, Schoenebeck +3 more
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When metal-catalyzed C–H functionalization meets visible-light photocatalysis
Beilstein Journal of Organic Chemistry, 2020 While aiming at sustainable organic synthesis, over the last decade particular attention has been focused on two modern fields, C–H bond activation, and visible-light-induced photocatalysis.
Lucas Guillemard, Joanna Wencel-Delord
doaj +1 more source
Photoredox C–H functionalization leads the site-selective phenylalanine bioconjugation
Scientific Reports, 2022 Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine ...
Yue Weng +3 more
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A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor [PDF]
, 2021 Photoredox catalysis has provided many approaches to C(sp3)-H functionalization that enable selective oxidation and C(sp3)-C bond formation via the intermediacy of a carbon-centered radical. While highly enabling, functionalization of the carbon-centered
Isabelle, Leibler +5 more
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Late-stage functionalization of pharmaceuticals, agrochemicals, and natural products
, 2023 Late-stage functionalization has become a method of choice for the rapid generation of chemical libraries. The high selectivity of these transformations provides great leverage for the agrochemical and pharmaceutical industries that rely on the fast ...
Selmi-Higashi, E +5 more
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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
Green Synthesis and Catalysis, 2023 C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (
Weidong Shang +3 more
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Electrochemical Benzylic C-H Functionalization with Isocyanides [PDF]
, 2021 We report the challenging direct carbamoylation or cyanation of benzylic C(sp3)-H bonds with an isocyanide via an electrochemical process giving rise to structures which are encountered in several biologically relevant compounds and drugs.
Guillaume, VINCENT +4 more
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Selective ring expansion and C−H functionalization of azulenes
Nature Communications, 2023 We report a transition metal-catalyzed ring expansion of azulene that can be contrasted with C–H functionalization. This study represents the first example of the successful ring expansion of azulene using Cu(hfacac)2 (hfacac: hexafluoroacetylacetonate ...
Sangjune Park +7 more
doaj +1 more source
, 2020 International audienceTransition metal-catalyzed C-H bond functionalization has known a rapid evolution in the last years, offering new strategies for reaching high molecular complexity in a step-and atom-economical way. Despite the indisputable advances,
Sara Mazeh +5 more
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