Tuning Benzylic C−H Functionalization of (Thio)xanthenes with Electrochemistry
Molecules, 2023 Here, we report a tunable electrochemical benzylic C−H functionalization of (thio)xanthenes with terminal alkynes and nitriles in the absence of any catalyst or external chemical oxidant.
Changji Wang +4 more
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Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines
Green Synthesis and Catalysis, 2022 Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharmaceuticals, natural products, material science and organometallics.
Linlin Shi, Tiantian Li, Guang-Jian Mei
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Ru-Catalyzed Selective C–H Functionalization of Pyridotriazoles with Acrylates
SynOpen, 2021 Ruthenium-catalyzed efficient and selective C–H alkenylation of pyridotriazoles with acrylates is described. The combination of metals (Ru and Fe) plays a crucial role in achieving quantitative yields of the desired products.
Abhisek Joshi +2 more
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Recent Advances on Synthetic Methodology Merging C–H Functionalization and C–C Cleavage
Molecules, 2020 The functionalization of C–H bonds has become a major thread of research in organic synthesis that can be assessed from different angles, for instance depending on the type of catalyst employed or the overall transformation that is carried out.
Hamid Azizollahi +1 more
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When metal-catalyzed C–H functionalization meets visible-light photocatalysis
Beilstein Journal of Organic Chemistry, 2020 While aiming at sustainable organic synthesis, over the last decade particular attention has been focused on two modern fields, C–H bond activation, and visible-light-induced photocatalysis.
Lucas Guillemard, Joanna Wencel-Delord
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Photoredox C–H functionalization leads the site-selective phenylalanine bioconjugation
Scientific Reports, 2022 Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine ...
Yue Weng +3 more
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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
Green Synthesis and Catalysis, 2023 C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (
Weidong Shang +3 more
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Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature
, 2020 Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment.
Narendra, Chaubey +2 more
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Ligand control of hydrocarbon C-H bond functionalization by uranyl photocatalysts
, 2023 The aqueous uranyl dication has long been known to facilitate the UV light-induced decomposition of aqueous VOCs (volatile organic compounds), via the long-lived highly efficient, uranyl excited state.
Polly, Arnold +8 more
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Transition-metal-free electrochemical-induced active C(sp3)-H functionalization
Green Chemistry Letters and Reviews, 2023 Direct C–H bond functionalization is the most effective technique to construct C–X (X = C, N, O, S, etc.), which could simplify the conventional synthesis methods.
Xiaolong Ma +4 more
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