Results 21 to 30 of about 28,198,830 (257)
Recent Advances on Synthetic Methodology Merging C–H Functionalization and C–C Cleavage
Molecules, 2020 The functionalization of C–H bonds has become a major thread of research in organic synthesis that can be assessed from different angles, for instance depending on the type of catalyst employed or the overall transformation that is carried out.
Hamid Azizollahi +1 more
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Ru-Catalyzed Selective C–H Functionalization of Pyridotriazoles with Acrylates
SynOpen, 2021 Ruthenium-catalyzed efficient and selective C–H alkenylation of pyridotriazoles with acrylates is described. The combination of metals (Ru and Fe) plays a crucial role in achieving quantitative yields of the desired products.
Abhisek Joshi +2 more
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Green Solvents for C-H Functionalization
, 2023 Organic solvents are ubiquitous in most of the synthetic processes and play a crucial role in influencing the chemical behavior of catalytic system and/or reactive species. Modern chemistry inevitably includes an evaluation of the chemical efficiency and
Rossini, Gabriele +3 more
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When metal-catalyzed C–H functionalization meets visible-light photocatalysis
Beilstein Journal of Organic Chemistry, 2020 While aiming at sustainable organic synthesis, over the last decade particular attention has been focused on two modern fields, C–H bond activation, and visible-light-induced photocatalysis.
Lucas Guillemard, Joanna Wencel-Delord
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Photoredox C–H functionalization leads the site-selective phenylalanine bioconjugation
Scientific Reports, 2022 Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine ...
Yue Weng +3 more
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Enantioselective Single and Dual a-C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer [PDF]
, 2022 Cyclic amines are ubiquitous structural motifs found in pharmaceuticals and biologically active natural products, making methods for their elaboration via direct C–H functionalization of considerable synthetic value.
Bo M. , Couture +5 more
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Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
Green Synthesis and Catalysis, 2023 C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (
Weidong Shang +3 more
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, 2020 International audienceTransition metal-catalyzed C-H bond functionalization has known a rapid evolution in the last years, offering new strategies for reaching high molecular complexity in a step-and atom-economical way. Despite the indisputable advances,
Sara Mazeh +5 more
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Remote C-H Functionalization of Aliphatic Amines [PDF]
This thesis summarizes our efforts in the development of methodologies aimed at remote C(sp3)–H functionalization of aliphatic amines. Amines are an important functional group present in a variety of biologically relevant molecules; however, examples of ...
Lee, Melissa
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Selective ring expansion and C−H functionalization of azulenes
Nature Communications, 2023 We report a transition metal-catalyzed ring expansion of azulene that can be contrasted with C–H functionalization. This study represents the first example of the successful ring expansion of azulene using Cu(hfacac)2 (hfacac: hexafluoroacetylacetonate ...
Sangjune Park +7 more
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