Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities [PDF]
ACS Central Science, 2016 The functionalization of C–H bonds has created new approaches to preparing organic molecules by enabling new strategic “disconnections” during the planning of a synthetic route.
John F. Hartwig, Matthew A. Larsen
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C–H Bond Functionalization of Amines: A Graphical Overview of Diverse Methods [PDF]
SynOpen, 2021 This Graphical Review provides a concise overview of the manifold and mechanistically diverse methods that enable the functionalization of sp3 C–H bonds in amines and their derivatives.
Subhradeep Dutta +4 more
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Ruthenium-catalyzed C–H bond functionalization in cascade and one-pot transformations
Coordination Chemistry Reviews, 2021 Ruthenium complexes are well known as remarkable pre-catalysts for challenging C–H bond functionalizations. Combining them with other types of chemical reactions in a tandem or one-pot fashion is appealing from a sustainable point of view because it ...
Rafael Gramage-Doria +1 more
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Structural basis for enzymatic terminal C-H bond functionalization of alkanes. [PDF]
Nat Struct Mol Biol, 2023 Alkane monooxygenase (AlkB) is a widely occurring integral membrane metalloenzyme that catalyzes the initial step in the functionalization of recalcitrant alkanes with high terminal selectivity. AlkB enables diverse microorganisms to use alkanes as their
Chai J +4 more
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A Perspective on Late-Stage Aromatic C-H Bond Functionalization. [PDF]
J Am Chem Soc, 2022 Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules.
Zhang L, Ritter T.
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Recent Advances in Regioselective C–H Bond Functionalization of Free Phenols [PDF]
Molecules, 2023 Phenols are important readily available synthetic building blocks and starting materials for organic synthetic transformations, which are widely found in agrochemicals, pharmaceuticals, and functional materials.
Yanan Li +3 more
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C–H bond functionalization reactions enabled by photobiocatalytic cascades
Green Synthesis and Catalysis, 2021 Light may participate in biocatalytic processes either by direct light-induced biocatalysis or by cascading light-induced chemical reactions with biocatalytic ones, which are acknowledged as photocatalysis.
Yuanying Li +3 more
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Biocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides. [PDF]
Angew Chem Int Ed Engl, 2021 Directed evolution of heme proteins has opened access to new-to-nature enzymatic activity that can be harnessed to tackle synthetic challenges. Among these, reactions resulting from active site iron-nitrenoid intermediates present a powerful strategy to ...
Athavale SV +5 more
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Molecules, 2021 Rollover cyclometalation constitutes a particular case of cyclometallation reaction. This reaction occurs when a chelated heterocyclic ligand loses its bidentate coordination mode and undergoes an internal rotation, after which a remote C–H bond is ...
Antonio Zucca, Maria I. Pilo
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Synthesis of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives via C-H Bond Functionalization of Disulfide Intermediates [PDF]
Molecules, 2022 Many nitrogen- and sulfur-containing heterocyclic compounds exhibit biological activity. Among these heterocycles are benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles for which two main synthetic approaches exist.
Luis G. Ardón-Muñoz +1 more
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