ACS Catalysis, 2020 Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the last years, offering modern strategies for reaching high molecular complexity in a step- and atom-economical...
Tatiana Besset
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Evolution of C-H Bond Functionalization from Methane to Methodology. [PDF]
J Am Chem Soc, 2016 This Perspective presents the fundamental principles, the elementary reactions, the initial catalytic systems, and the contemporary catalysts that have converted C−H bond functionalization from a curiosity to a reality for synthetic chemists.
Hartwig JF.
europepmc +4 more sources
Recent Advances in C–H Bond Functionalization with Ruthenium-Based Catalysts
Catalysts, 2019 The past decades have witnessed rapid development in organic synthesis via catalysis, particularly the reactions through C–H bond functionalization. Transition metals such as Pd, Rh and Ru constitute a crucial catalyst in these C–H bond functionalization
Keisham S Singh
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Multiple Catalytic C-H Bond Functionalization for Natural Product Synthesis. [PDF]
Angewandte Chemie, 2020 In the past decade, multiple catalytic C-H bond functionalization has been successfully applied in natural product synthesis as a strategy to reduce the number of steps, increase overall yield and employ more easily available starting materials.
O. Baudoin
semanticscholar +2 more sources
Condensation-Based Methods for the C-H Bond Functionalization of Amines. [PDF]
Synthesis (Stuttg), 2021 This review aims to provide a comprehensive overview of condensation-based methods for the C–H bond functionalization of amines that feature azomethine ylides as key intermediates.
Chen W, Seidel D.
europepmc +2 more sources
C–H bond functionalization: recent discoveries and future directions [PDF]
Beilstein Journal of Organic Chemistry, 2023 Indranil Chatterjee
doaj +2 more sources
Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity. [PDF]
Curr Opin Chem Biol, 2019 C—H functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of C—H oxidations in biology.
Zhang RK, Huang X, Arnold FH.
europepmc +2 more sources
Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization. [PDF]
European J Org Chem, 2019 In this study, we combined photo‐organo redox catalysis and biocatalysis to achieve asymmetric C–H bond functionalization of simple alkane starting materials.
Zhang W +7 more
europepmc +2 more sources
Direct α-C-H bond functionalization of unprotected cyclic amines. [PDF]
Nat Chem, 2018 Cyclic amines are ubiquitous core structures of bioactive natural products and pharmaceutical drugs. Although the site-selective abstraction of C–H bonds is an attractive strategy for preparing valuable functionalized amines from their readily available ...
Chen W, Ma L, Paul A, Seidel D.
europepmc +2 more sources
Diversification of Unprotected Alicyclic Amines by C−H Bond Functionalization: Decarboxylative Alkylation of Transient Imines [PDF]
Angewandte Chemie - International Edition, 2021 Daniel Seidel, Jae Hyun Kim
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