Results 31 to 40 of about 52,780 (297)

Distal Functionalization via Transition Metal Catalysis

Chemistry Proceedings, 2022
The ubiquitous presence of sp3 C−H bonds in natural feedstock makes them inexpensive, easily accessible, and attractive synthons for the preparation of common and/or complex molecular frameworks in biologically active natural products, pharmaceutics ...
Haibo Ge
doaj   +1 more source

Evolution of C-H Bond Functionalization from Methane to Methodology. [PDF]

J Am Chem Soc, 2016
This Perspective presents the fundamental principles, the elementary reactions, the initial catalytic systems, and the contemporary catalysts that have converted C-H bond functionalization from a curiosity to a reality for synthetic chemists.
Hartwig JF.
europepmc   +2 more sources

Synthesis of Phthalides and α,β-butenolides by Transition Metal-Catalyzed Activation of C—H Bonds

Molecules, 2019
Phthalides and α,β-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on C—H bond functionalization reactions, in which two
Andrea Renzetti, Kozo Fukumoto
doaj   +1 more source

A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor [PDF]

, 2021
Photoredox catalysis has provided many approaches to C(sp3)-H functionalization that enable selective oxidation and C(sp3)-C bond formation via the intermediacy of a carbon-centered radical. While highly enabling, functionalization of the carbon-centered
Isabelle, Leibler, Abigail, Doyle, Leibler, Isabelle Nathalie-Marie, Tekle-Smith, Makeda A, Doyle, Abigail G, Makeda A., Tekle-Smith   +5 more
core   +1 more source

Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Green Synthesis and Catalysis, 2023
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang, Fei Liu, Feihua Du, Linghui Zeng, Zhiyuan Chen   +4 more
doaj   +1 more source

Multiple Catalytic C-H Bond Functionalization for Natural Product Synthesis [PDF]

, 2020
In the past decade, multiple catalytic C-H bond functionalization has been successfully applied in natural product synthesis as a strategy to reduce the number of steps, increase overall yield and employ more easily available starting materials.
Baudoin, Olivier
core   +1 more source

Radical‐Promoted Distal C‐H Functionalization of C(sp3) Centers with Fluorinated Moieties

, 2020
International audienceDue to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals and materials science.
Tatiana Besset, Thomas Castanheiro, Nobile, Enzo, Castanheiro, Thomas, Besset, Tatiana, Enzo Nobile   +5 more
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Enantioselective Single and Dual a-C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

, 2022
Cyclic amines are ubiquitous structural motifs found in pharmaceuticals and biologically active natural products, making methods for their elaboration via direct C–H functionalization of considerable synthetic value.
Bo M. , Couture, Manjinder S. , Lall, Ningyu, Liu, Rudi, Fasan, Jeffrey T. , Kohrt, Xinkun, Ren   +5 more
core   +1 more source

Robust molecular trends in Pd-catalyzed C(sp2/sp3)-H activation reactions – A review

Results in Chemistry, 2021
Direct functionalization of inert C–H bonds into various C-X (X = C, N, O, S) functionalities is one of the frontier research topics and regularly gaining popularities among the communities of scientists by providing opportunities for direct synthesis of
Pravati Panda, Kaushik Pal, Subhendu Chakroborty   +2 more
doaj   +1 more source

Cobalt catalyzed decarbonylative ipso-C-C bond functionalization: Synthesis of Indole C-3 functionalized acyloins using 1,2-diketone

, 2022
Selective functionalization of indole C3-C bond with aromatic/heteroaromatic 1,2-diketones has been uncovered for the first time. Earth crust abundant first-row transition metal cobalt catalyst has been demonstrated as an effective catalyst for this ...
Saista , Afreen, Tanmayee, Nanda, Gopal Krusna Das , Adhikari, Ponneri C., Ravikumar, Naupada , Preeyanka, Shyam Kumar, Banjare   +5 more
core   +1 more source