Results 41 to 50 of about 52,780 (297)

Arenes and Heteroarenes C–H Functionalization Under Enabling Conditions: Electrochemistry, Photoelectrochemistry & Flow Technology

, 2023
C-H bond functionalization generates molecular complexity in single-step transformation. However, the activation of C-H bonds requires expensive metals or stoichiometric amounts of oxidizing/reducing species.
Ayesha , Murtaza, Bahareh, Shirinfar, Zia , ulhaq, Guilherme M. , Martins, Samina , Aslam, Nisar, Ahmed, Sadia , Rani   +6 more
core   +1 more source

Silver-Mediated Direct sp(3) C-H Bond Functionalization

, 2015
Direct sp(3) C-H bond functionalization is an efficient, straightforward, and powerful method to construct new C-X (X = C, N, F, S) bonds from nonfunctionalized aliphatic motif of organic molecules, which has been used in late-stage modification of ...
Zhou, Taigang, Zhang-Jie Shi, Shi, Zhang-Jie, Taigang Zhou   +3 more
core   +1 more source

Recent Advances in the Nickel-Catalyzed Alkylation of C-H Bonds

Molecules
Functionalization of C-H bonds has emerged as a powerful strategy for converting inert, nonfunctional C-H bonds into their reactive counterparts.
Franc Požgan, Uroš Grošelj, Jurij Svete, Bogdan Štefane, Hamad H. Al Mamari   +4 more
doaj   +1 more source

Enantioselective C–P Bond Formation through C(sp3)–H Functionalization

, 2023
An unprecedented enantioselective C–P bond formation has been developed through a C(sp3)–H activation in an oxidation step followed by an organocatalyzed hydrophosphonylation protocol. The asymmetric organocatalytic Pudovik reaction has been successfully
Devan , Horn, Raquel, P. Herrera, M. Concepción , Gimeno, Sandra, Ardevines, Juan V. , Alegre-Requena, Marta , González-Jiménez, Eugenia , Marqués-López   +6 more
core   +1 more source

Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage

Research, 2020
As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and elastomers.
Jianzhong Liu, Jun Pan, Xiao Luo, Xu Qiu, Cheng Zhang, Ning Jiao   +5 more
doaj   +1 more source

Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature

, 2020
Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment.
Narendra, Chaubey, Biswanath, Maity, Anant, Kapdi   +2 more
core   +1 more source

Recent Developments in Transition-Metal Catalyzed Direct C–H Alkenylation, Alkylation, and Alkynylation of Azoles

Molecules, 2020
The transition metal-catalyzed C–H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C–H functionalization of various heteroarenes,
Su Chen, Prabhat Ranjan, Leonid G. Voskressensky, Erik V. Van der Eycken, Upendra K. Sharma   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source