Results 61 to 70 of about 52,780 (297)

Palladium-Catalyzed C−H Bond Functionalization with Arylsulfonyl Chlorides

, 2016
Palladium-Catalyzed C−H Bond Functionalization with Arylsulfonyl ...
Vy M. Dong (1311219), Xiaodan Zhao (136112), Elena Dimitrijević (1433659)   +2 more
core   +2 more sources

Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles

Nature Communications, 2021
Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-
Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao, Rui Wang, Depeng Zhao   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Toward Rational Understandings of α-C–H Functionalization: Energetic Studies of Representative Tertiary Amines

iScience, 2020
Summary: Functionalization of α-C–H bonds of tertiary amines to build various α-C–X bonds has become a mainstream in synthetic chemistry nowadays. However, due to lack of fundamental knowledge on α-C–H bond strength as an energetic guideline, rational ...
Wenzhi Luo, Jin-Dong Yang, Jin-Pei Cheng
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Applications of Catalytic Organometallic C(sp3)–H Bond Functionalization

, 2015
The transition-metal-catalyzed activation of C(sp3)–H bonds has emerged as powerful strategy to create bonds and introduce functional groups in a direct fashion.
Grégory Danoun, Dailler, David, Danoun, Grégory, David Dailler, Baudoin, Olivier, Olivier Baudoin   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Electrochemical Benzylic C-H Functionalization with Isocyanides

, 2021
We report the challenging direct carbamoylation or cyanation of benzylic C(sp3)-H bonds with an isocyanide via an electrochemical process giving rise to structures which are encountered in several biologically relevant compounds and drugs.
Guillaume, VINCENT, Laurence, Grimaud, Régis, Guillot, Maxime, Vitale, Shanyu, Tang   +4 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

An Atomically Dispersed Photocatalyst for para-Selective C-H bond Functionalization of Electron-Poor Arenes

Regioselective C-H bond functionalization is pivotal in modern scientific exploration, offering solutions for achieving novel synthetic methodologies and pharmaceutical development.
Suman , Pradhan, Jun , Hu, Giovanni , Barcaro, Joaquin , Silvestre-Albero, Jabor , Rabeah, Sandra , Van Aert, Susanna , Monti, Xingchao , Dai, Piotr , Kuśtrowski, Shoubhik, Das, Aleksander , Jaworski, Veronica , Celorrio, Peng , Ren, Yuman, Qin, Sara , Bals, Noopur , Jain, Anna , Rokicińska   +16 more
core   +1 more source