Results 71 to 80 of about 27,304,717 (282)
Electroreductive Deoxygenative C–H and C–C Bond Formation from Non-Derivatized Alcohols Fueled by Borohydride Oxidation [PDF]
, 2023 Alcohols are one of the most common organic compound classes among natural and synthetic products. Thus, methods for direct removal of C–OH groups without the need for wasteful pre-functionalization are of great synthetic interest to unlock the full ...
Hemlata, Agarwala +8 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Green Chemistry Letters and ReviewsTetrahydroisoquinolines (THIQs) are a significant class of nitrogen-containing heterocyclic compounds often occurring in natural products and pharmaceuticals, exhibiting excellent biological activities and chemical properties, and also having a wide ...
Kai Yang +5 more
doaj +1 more source
Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
Nature Communications, 2021 Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-
Zhe Chang +6 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Applications of Catalytic Organometallic C(sp3)–H Bond Functionalization
, 2015 The transition-metal-catalyzed activation of C(sp3)–H bonds has emerged as powerful strategy to create bonds and introduce functional groups in a direct fashion.
Grégory Danoun +5 more
core +1 more source
Palladium-Catalyzed C−H Bond Functionalization with Arylsulfonyl Chlorides
, 2016 Palladium-Catalyzed C−H Bond Functionalization with Arylsulfonyl ...
Vy M. Dong (1311219) +2 more
core +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Radical-Mediated Regiodivergent C(sp3)–H Functionalization of N-Substituted Indolines via Enzymatic Carbene Transfer [PDF]
Indolines are ubiquitous structural motifs found in pharmaceuticals and natural products but modification of these scaffolds via selective C(sp3)–H functionalization represents a major challenge.
Ru, Cui +4 more
core +1 more source