Results 91 to 100 of about 28,758,506 (252)
Copper catalysis in arene and heteroarene functionalization through C-H bond activation
, 2012 A review was given on providing a comprehensive overview on arene and heteroarene functionalization by C-H bond activation. In general, reactions based on the use of a stoichiometric amt. of copper are not discussed herein. Copper-catalyzed arene and
GOGGIAMANI, ANTONELLA +5 more
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
, 2016 Chelating N-Heterocyclic Carbene Alkoxide as a Supporting Ligand for PdII/IV C−H Bond Functionalization ...
Melanie S. Sanford (1246980) +2 more
core +3 more sources
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Recent advances in C(sp3)–H bond functionalization via metal–carbene insertions
Beilstein Journal of Organic Chemistry, 2016 The recent development of intermolecular C–H insertion in the application of C(sp3)–H bond functionalizations, especially for light alkanes, is reviewed.
Bo Wang, Di Qiu, Yan Zhang, Jianbo Wang
doaj +1 more source
C–H Functionalization on Carbohydrates
, 2016 Functionalization of C–H bonds has received significant attention in organic chemistry during the last decade and it is still a “hot” topic. In particular, C–H modification of natural products has benefitted from this development.
Pedersen, Christian Marcus +8 more
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Synthesis of (−)-Muricatacin via α- and α‘-C−H Bond Functionalization of Tetrahydrofuran
, 2016 (−)-Muricatacin, a potent cytotoxic (4R,5R)-5-hydroxyheptadecan-4-olide, has been synthesized through α-C−H hydroxyalkylation and α‘-C−H oxidation of tetrahydrofuran.
Takehiko Yoshimitsu (1696108) +2 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2019 The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)–H bond functionalization (cross-dehydrogenative ...
Bondžić, Bojan, Džambaski, Zdravko
core +1 more source