Results 81 to 90 of about 52,780 (297)

Non-covalent organocatalysis in asymmetric oxidative C(sp3)–H bond functionalization – broadening C–H bond coupling reactions

, 2016
Among the current huge development activities in C-H functionalization, asymmetric oxidative C(sp(3))-H bond coupling strategies have remained underrepresented. Beyond the initial examples using chiral metal complexes, the use of organocatalysis provides
Stockerl, Sebastian, Mancheño, Olga García   +1 more
core   +1 more source

Electroreductive Deoxygenative C–H and C–C Bond Formation from Non-Derivatized Alcohols Fueled by Borohydride Oxidation

, 2023
Alcohols are one of the most common organic compound classes among natural and synthetic products. Thus, methods for direct removal of C–OH groups without the need for wasteful pre-functionalization are of great synthetic interest to unlock the full ...
Hemlata, Agarwala, Adrian, Soto Kronberg, Victoria, Chu, Mårten, Ahlquist, Piret, Villo, Guillermo, Ahumada, Helena, Lundberg, Malin, Lill, Zainab, Alsaman   +8 more
core   +1 more source

N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C–H Functionalization

Molecules
Chelation-assisted olefinic C–H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones.
Yawei Zhang, Chengxing Peng, Xiaoli Li, Xiuying Liu, Liyuan Ding, Guofu Zhong, Jian Zhang   +6 more
doaj   +1 more source

Traceless Redox-Annulations of Alicyclic Amines

SynOpen, 2020
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox­-neutral annulations with ortho-(nitromethyl)benzaldehyde. Benzoic­ acid acts as a promoter in these reactions, which involve concurrent amine α-C–H bond and N–H bond functionalization ...
Dillon R. L. Rickertsen, Longle Ma, Anirudra Paul, Khalil A. Abboud, Daniel Seidel   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Electrocatalytic C(sp3)-H bond functionalization using biomass-derived electrodes

Nature Communications
Organic electrosynthesis is a versatile and evergreen tool for constructing chemical compounds. However, the study of highly active electrodes has not received enough attention, which limits the further development of organic electrosynthesis.
Lijun Lu, Yan Li, Hao Li, Xueyu Jiang, Xianglin Pei, Dali Yang, Yu-Chung Chang, Jeng-Lung Chen, Fan Liao, Aiwen Lei   +9 more
doaj   +1 more source

Photo-driven redox-neutral decarboxylative carbon-hydrogen trifluoromethylation of (hetero)arenes with trifluoroacetic acid

Nature Communications, 2017
C–H bond functionalization has become an important tool for many organic transformations, however such reactions typically require stoichiometric amounts of external oxidants.
Jin Lin, Zhi Li, Jian Kan, Shijun Huang, Weiping Su, Yadong Li   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Transition metal-catalyzed site- and regio-divergent C-H bond functionalization

, 2021
Recent advances in transition metal-catalyzed C-H bond functionalization have profoundly impacted synthetic strategy. Since organic substrates typically contain several chemically distinct C-H bonds, controlling the regioselectivity of C-H bond ...
이상기, Jean Bouffard
core   +1 more source

Enantioselective functionalization of unactivated C(sp3)–H bonds through copper-catalyzed diyne cyclization by kinetic resolution

Nature Communications
Site- and stereoselective C–H functionalization is highly challenging in the synthetic chemistry community. Although the chemistry of vinyl cations has been vigorously studied in C(sp3)–H functionalization reactions, the catalytic enantioselective C(sp3)–
Yang-Bo Chen, Li-Gao Liu, Zhe-Qi Wang, Rong Chang, Xin Lu, Bo Zhou, Long-Wu Ye   +6 more
doaj   +1 more source