Results 81 to 90 of about 28,758,506 (252)
Nature CommunicationsSite- and stereoselective C–H functionalization is highly challenging in the synthetic chemistry community. Although the chemistry of vinyl cations has been vigorously studied in C(sp3)–H functionalization reactions, the catalytic enantioselective C(sp3)–
Yang-Bo Chen +6 more
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C–H Activation via Group 8–10 Pincer Complexes: A Mechanistic Approach
InorganicsC–H bond activation is a crucial synthetic strategy widely utilized in both academic and industrial settings. Due to the strong and kinetically inert nature of the C–H bond, its functionalization typically requires metal-based catalysts.
Juan S. Serrano-García +5 more
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Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
, 2016 Cu-Facilitated C−O Bond Formation Using N-Hydroxyphthalimide: Efficient and Selective Functionalization of Benzyl and Allylic C−H ...
Seung Hwan Cho (1419937) +3 more
core +2 more sources
, 2016 Selective Functionalization of Amino Acids in Water: A Synthetic Method via Catalytic C−H Bond ...
Dalibor Sames (1432975) +2 more
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Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
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, 2013 Significant progress has been accomplished in direct olefinations through twofold C-H bond functionalization of arenes and heteroarenes employing readily accessible, selective and relatively inexpensive ruthenium catalysts.
Ackermann, Lutz, Kozhushkov, Sergei I.
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Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Geminal group-directed olefinic C-H functionalization via four- to eight-membered exo-metallocycles
Nature Communications, 2019 Identifying distinct cyclometallation pathways is essential to new types of C-H activation and functionalization in organic synthesis. Here, the authors show the activation of an olefinic C-H bond geminal to the directing group via four- to eight ...
Keke Meng +5 more
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