Results 81 to 90 of about 27,304,717 (282)

Theoretical and experimental studies of palladium-catalyzed site-selective C(sp3)−H bond functionalization enabled by transient ligands [PDF]

, 2017
Transition metal-catalyzed selective C–H bond functionalization enabled by transient ligands has become an extremely attractive topic due to its economical and greener characteristics.
Ke, Yang, Jianyi, Wang, Haibo, Ge, Piaoping, Tang, Guigen, Li, Mian, Wang, Lei, Pan   +6 more
core   +2 more sources

Recent developments in photoredox-catalyzed remote ortho and para C–H bond functionalizations

Beilstein Journal of Organic Chemistry, 2020
In recent years, the research area of direct C–H bond functionalizations was growing exponentially not only due to the ubiquity of inert C–H bonds in diverse organic compounds, including bioactive natural and nonnatural products, but also due to its ...
Rafia Siddiqui, Rashid Ali
doaj   +1 more source

Toward Rational Understandings of α-C–H Functionalization: Energetic Studies of Representative Tertiary Amines

iScience, 2020
Summary: Functionalization of α-C–H bonds of tertiary amines to build various α-C–X bonds has become a mainstream in synthetic chemistry nowadays. However, due to lack of fundamental knowledge on α-C–H bond strength as an energetic guideline, rational ...
Wenzhi Luo, Jin-Dong Yang, Jin-Pei Cheng
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Catalyst-Controlled C–H Functionalization of Adamantanes Using Selective H‑Atom Transfer [PDF]

, 2018
A method for the direct functionalization of diamondoids has been developed using photoredox and H atom transfer catalysis. This C–H alkylation reaction has excellent chemoselectivity for the strong 3° C–H bonds of adamantanes in polyfunctional molecules.
Abigail Feceu (5237030), Hai-Bin, Yang, David Martin (6028910), Hai-Bin Yang (1819423), Abigail Feceu (6035636), Hai-Bin Yang, Abigail Feceu, Hai-Bin Yang (6035633), David B. C. Martin (2386141), David, Martin, David B. C. Martin, Abigail, Feceu   +11 more
core   +1 more source

Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp3–H bond oxidative functionalization of acetonitrile

Nature Communications, 2019
Direct α-functionalization of acetonitrile, a bulk chemical, is usually limited to its enolate chemistry. Here, the authors show an electro-oxidative C(sp3)–H bond functionalization of acetonitrile with thiols to afford tetrasubstituted olefins with high
Tian-Jun He, Zongren Ye, Zhuofeng Ke, Jing-Mei Huang   +3 more
doaj   +1 more source

Pyridine C(sp2)–H bond functionalization under transition-metal and rare earth metal catalysis

Beilstein Journal of Organic Chemistry, 2023
Pyridine is a crucial heterocyclic scaffold that is widely found in organic chemistry, medicines, natural products, and functional materials. In spite of the discovery of several methods for the synthesis of functionalized pyridines or their integration ...
Haritha Sindhe, Malladi Mounika Reddy, Karthikeyan Rajkumar, Akshay Kamble, Amardeep Singh, Anand Kumar, Satyasheel Sharma   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source