Results 51 to 60 of about 28,758,506 (252)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Green Chemistry Letters and ReviewsTetrahydroisoquinolines (THIQs) are a significant class of nitrogen-containing heterocyclic compounds often occurring in natural products and pharmaceuticals, exhibiting excellent biological activities and chemical properties, and also having a wide ...
Kai Yang +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Selective C-H and C-C Bond Functionalization of Benzo-Fused N-Heteroaromatic Compounds [PDF]
, 2022 Supervisor: Das, AnimeshThe present thesis, entitled “Selective C-H and C-C Bond Functionalization of Benzo-Fused N-Heteroaromatic Compounds” is divided into five chapters based on the results obtained from the experimental works during the course of PhD
Sarmah, Bikash Kumar
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles
Nature Communications, 2021 Late-stage C(sp3)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here the authors show copper-catalysed late-stage C(sp3)-
Zhe Chang +6 more
doaj +1 more source
Rhodium-Catalyzed C–H Bond Functionalization with Amides by Double C–H/C–N Bond Activation
, 2016 The first C–H bond functionalization with amides as the coupling partners via selective activation of the amide N–C bond using rhodium(I) catalysts under highly chemoselective conditions is reported.
Michal Szostak (1305681) +1 more
core +1 more source
Theoretical and experimental studies of palladium-catalyzed site-selective C(sp3)−H bond functionalization enabled by transient ligands [PDF]
, 2017 Transition metal-catalyzed selective C–H bond functionalization enabled by transient ligands has become an extremely attractive topic due to its economical and greener characteristics.
Ke, Yang +6 more
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2016 Rhodium-Catalyzed Regioselective C−H Functionalization via Decarbonylation of Acid Chlorides and C−H Bond Activation under Phosphine-Free ...
Zhengkun Yu (1489108) +1 more
core +1 more source