A Transient Directing Group Strategy Enables Enantioselective Multicomponent Organofluorine Synthesis. [PDF]
J Am Chem Soc, 2021 The vicinal fluorofunctionalization of alkenes represents an expedient strategy for converting feedstock olefins into valuable fluorinated molecules and as such has garnered significant attention from the synthetic community; however, current methods ...
Liu Z +6 more
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Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes. [PDF]
Nat Chem, 2022 In the absence of directing auxiliaries, the catalytic addition of carbogenic groups to unactivated alkenes with control of regioselectivity remains an ongoing challenge in organic chemistry.
Wang H +4 more
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Progress in Catalytic Asymmetric Reactions with 7-Azaindoline as the Directing Group [PDF]
Molecules, 2023 α-Substituted-7-azaindoline amides and α,β-unsaturated 7-azaindoline amides have emerged as new versatile synthons for various metal-catalyzed and organic-catalyzed asymmetric reactions, which have attracted much attention from chemists.
Yan-Ping Zhang +5 more
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PdII -Catalyzed C(alkenyl)-H Activation Facilitated by a Transient Directing Group. [PDF]
Angew Chem Int Ed Engl, 2022 Palladium(II)‐catalyzed C(alkenyl)−H alkenylation enabled by a transient directing group (TDG) strategy is described. The dual catalytic process takes advantage of reversible condensation between an alkenyl aldehyde substrate and an amino acid TDG to ...
Liu M +6 more
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A "Traceless" Directing Group Enables Catalytic SN2 Glycosylation toward 1,2-cis-Glycopyranosides. [PDF]
J Am Chem Soc, 2021 Generally applicable and stereoselective formation of 1,2-cis-glycopyranosidic linkage remains a long sought after yet unmet goal in carbohydrate chemistry. This work advances a strategy to this challenge via stereoinversion at the anomeric position of 1,
Ma X +5 more
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Palladium-catalyzed direct asymmetric C-H bond functionalization enabled by the directing group strategy. [PDF]
Chem Sci, 2020 In the past decade, selective C–C and C-heteroatom bond construction through palladium-catalyzed direct C–H bond functionalization has been extensively studied by employing a variety of directing groups.
Yang K, Song M, Liu H, Ge H.
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Transient Directing Group Enabled Pd-catalyzed γ-C(sp3)-H Oxygenation of Alkyl Amines. [PDF]
ACS Catal, 2020 We report a general protocol for γ-C(sp3)–H acyloxylation and alkoxylation of free amines using 2-hydroxynicotinaldehyde as the transient directing group.
Chen YQ, Wu Y, Wang Z, Qiao JX, Yu JQ.
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Palladium-catalyzed asymmetric migratory diarylation of unactivated directing-group-free internal alkenes [PDF]
Nature CommunicationsEnantioselective dicarbofunctionalization of alkenes is a powerful strategy for constructing functionalized sp³-rich molecules, yet it remains challenging for unactivated substrates lacking directing groups.
Linlin Fan +6 more
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Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group [PDF]
Nature Communications, 2021 The synthesis of regio- and stereo-defined alkenes with multiple alkyl substituents is an unmet challenge. Here, the authors report a nickel-catalyzed intermolecular cross-dialkylation of alkynes devoid of directing or activating groups to afford ...
Yi-Zhou Zhan, Nan Xiao, Wei Shu
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PdII -Catalyzed Enantioselective C(sp3 )-H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group. [PDF]
Angew Chem Int Ed Engl, 2020 The utilization of chiral transient directing groups (TDGs) has recently emerged as a promising approach for developing Pd(II)-catalyzed enantioselective C(sp3)−H activation reactions.
Xiao LJ +6 more
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