Synthetic and Mechanistic Studies of a Versatile Heteroaryl Thioether Directing Group for Pd(II) Catalysis. [PDF]
ACS Catal, 2019 A weakly coordinating monodentate heteroaryl thioether directing group has been developed for use in Pd(II) catalysis to orchestrate key elementary steps in the catalytic cycle that require conformational flexibility in a manner that is difficult to ...
Romine AM +4 more
europepmc +12 more sources
Amine‐Catalyzed Copper‐Mediated C−H Sulfonylation of Benzaldehydes via a Transient Imine Directing Group** [PDF]
Angewandte Chemie - International Edition, 2022 Transient directing groups (TDGs) can provide a powerful means for C–H functionalization without requiring additional steps for directing group introduction and removal.
Joe I Higham, James A Bull
exaly +4 more sources
Directing-Group-Enabled Cycloaddition of Azides and Alkynes toward Functionalized Triazoles.
Organic Letters, 2020 Herein, we report a directing-group-enabled Huisgen cycloaddition of azides and alkynes for the synthesis of functionalized triazoles in which the triazene group could act as a directing group to enable this regioselective [3 + 2] cycloaddition and ...
Linwei Zeng +4 more
semanticscholar +2 more sources
Journal of the American Chemical Society, 2021 Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones.
Philip A Provencher +6 more
semanticscholar +2 more sources
Directing-Group-Assisted Manganese-Catalyzed Cyclopropanation of Indoles.
Organic Letters, 2019 The first manganese-catalyzed cyclopropanation of indoles is reported in moderate to excellent yield with methyl-2-diazo-2-arylacetates. This new strategy involved acetyl (COCH3) as the directing group and exhibited exceptional functional group tolerance.
P. K. Dutta +3 more
semanticscholar +3 more sources
Angewandte Chemie, 2019 Metal-coordinating directing groups have seen extensive use in the field of transition-metal-catalysed alkene functionalization; however, their waste-generating installation and removal steps limit the efficiency and practicality of reactions that rely ...
Lucas J. Oxtoby +6 more
semanticscholar +2 more sources
Stereospecific syn-dichlorination of allylic amines enabled by identification of a superior stereo-directing group [PDF]
Communications ChemistryAlteration of a well-established reaction mechanism for access to different molecular structures is an inherently intriguing research subject. In that context, syn-stereospecific alkene dihalogenation draws attention as a long-standing problem in ...
Jeong Kyun Im +2 more
doaj +2 more sources
When is an Imine Directing Group a Transient Imine Directing Group in C-H Functionalization?
Chemistry'Transient' C-H functionalization has emerged in recent years to describe the use of a dynamic linkage, often an imine, to direct cyclometalation and subsequent functionalization.
Joe I Higham, Tsz-Kan Ma, James A. Bull
semanticscholar +2 more sources
Catalyst-controlled directing group translocation in the site selective C–H functionalization of 3-carboxamide indoles and metallocarbenes [PDF]
Nature CommunicationsComplementary methods toward the selective functionalization of indole and oxindole frameworks employing an alternative strategy in heteroaryl C–H functionalizations are presented herein.
Kuang Gu +4 more
doaj +2 more sources
Directing-Group-Free Arene C(sp2)-H Amination Using Bulky Aminium Radicals and DFT Analysis of Regioselectivity. [PDF]
J Org Chem, 2023 A hydroxylamine-derived electrophilic aminating reagent produces a transient and bulky aminium radical intermediate upon in situ activation by either TMSOTf or TFA and a subsequent electron transfer from an iron(II) catalyst.
Behnke NE +4 more
europepmc +3 more sources