Results 241 to 250 of about 7,841,789 (286)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Copper-oxygen adducts: new trends in characterization and properties towards C-H activation. [PDF]

Chem Sci
De Tovar J, Leblay R, Wang Y, Wojcik L, Thibon-Pourret A, Réglier M, Simaan AJ, Le Poul N, Belle C.   +8 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Na-Promoted Bimetallic Hydroxide Nanoparticles for Aerobic C-H Activation: Catalyst Design Principles and Insights into Reaction Mechanism. [PDF]

ACS Appl Mater Interfaces
Erdivan B, Calikyilmaz E, Bilgin S, Erdali AD, Gul DN, Ercan KE, Türkmen YE, Ozensoy E.   +7 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Enhancing the nucleophilicity of aluminyl anions: targeting selective C-H activation. [PDF]

Chem Sci
Kallmeier F, Nelmes GR, McMullin CL, Edwards AJ, Hicks J.   +4 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Noncovalent interaction with a spirobipyridine ligand enables efficient iridium-catalyzed C-H activation. [PDF]

Nat Commun
Jin Y, Ramadoss B, Asako S, Ilies L.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Tandem Cu(I)-Catalyzed Dipolar Cycloaddition-C-H Activation for the In-Flow Synthesis of <i>N</i>-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates. [PDF]

Org Lett
Donato E, Mayorquín-Torres MC, Puglisi A, Benaglia M, Adamo MFA, Stevens CV.   +5 more
europepmc   +1 more source