Results 261 to 270 of about 7,841,789 (286)

Decoding directing groups and their pivotal role in C-H activation.

Chemistry, 2021
Synthetic organic chemistry has witnessed a plethora of functionalization and defunctionalization strategies. In this regard, C-H functionalization has been at the forefront due to the multifarious applications in the development of simple to complex ...
Karunanidhi Murali, Luana A. Machado, Renato L Carvalho, Leandro F. Pedrosa, Rishav Mukherjee, Eufrânio N. da Silva Júnior, D. Maiti   +6 more
semanticscholar   +1 more source

Twofold C-H Activation-Based Enantio- and Diastereoselective C-H Arylation Using Diarylacetylenes as Rare Arylating Reagents.

Angewandte Chemie, 2021
C-H bond activation has been established as an attractive strategy to access axially chiral biaryls, and the most straightforward method is direct C-H arylation of arenes.
Panjie Hu, Lingheng Kong, Fen Wang, Xiaolin Zhu, Xingwei Li   +4 more
semanticscholar   +1 more source

Metalla-electrocatalyzed C-H Activation by Earth-Abundant 3d Metals and Beyond.

Accounts of Chemical Research, 2019
To improve the efficacy of molecular syntheses, researchers wish to capitalize upon the selective modification of otherwise inert C-H bonds. The past two decades have witnessed considerable advances in coordination chemistry that have set the stage for ...
L. Ackermann
semanticscholar   +1 more source

Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals.

Angewandte Chemie, 2019
Molecular syntheses largely rely on time- and labour-intensive prefunctionalization strategies. In contrast, C-H activation represents an increasingly powerful approach that avoids lengthy syntheses of prefunctionalized substrates, with great potential ...
Joachim Loup, Uttam Dhawa, Fabio Pesciaioli, J. Wencel‐Delord, L. Ackermann   +4 more
semanticscholar   +1 more source

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C-H Activation and Nucleophilic Cyclization.

Journal of the American Chemical Society, 2019
Enantiomeric access to pentatomic biaryls is challenging due to their relatively low rotational barrier. Reported herein is the mild and highly enantioselective synthesis of 2,3'-biindolyls via underexplored integration of C-H activation and alkyne ...
M. Tian, Dachang Bai, G. Zheng, Junbiao Chang, Xingwei Li   +4 more
semanticscholar   +1 more source

Electrocatalytic C–H Activation

ACS Catalysis, 2018
C–H activation has emerged as a transformative tool in molecular synthesis, but until recently oxidative C–H activations have largely involved the use of stoichiometric amounts of expensive and toxic metal oxidants, compromising the overall sustainable ...
Nicolas Sauermann, T. H. Meyer, Y. Qiu, L. Ackermann   +3 more
semanticscholar   +1 more source

Late-Stage Peptide Diversification by Position-Selective C-H Activation.

Angewandte Chemie, 2018
The late-stage modification of structurally complex peptides bears great potential for drug discovery, crop protection, and the pharmaceutical industry, among others.
Wei Wang, Mélanie M. Lorion, Jagrut A. Shah, A. Kapdi, L. Ackermann   +4 more
semanticscholar   +1 more source

Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation.

Angewandte Chemie, 2019
The first enantioselective Satoh-Miura-type reaction is reported. A variety of C-N axially chiral N-aryloxindoles have been enantioselectively synthesized by an asymmetric rhodium-catalyzed dual C-H activation reaction of N-aryloxindoles and alkynes ...
Honghe Li, Xiaoqian Yan, Jitan Zhang, Weicong Guo, Jijun Jiang, Jun Wang   +5 more
semanticscholar   +1 more source

Experimental Evidence for p Ka-Driven Asynchronicity in C-H Activation by a Terminal Co(III)-Oxo Complex.

Journal of the American Chemical Society, 2019
C-H activation by transition metal oxo complexes is a fundamental reaction in oxidative chemistry carried out by both biological and synthetic systems. This centrality has motivated efforts to understand the patterns and mechanisms of such reactivity. We
M. Goetz, John S. Anderson
semanticscholar   +1 more source

Flow Rhodaelectro-Catalyzed Alkyne Annulations by Versatile C-H Activation: Mechanistic Support for Rhodium(III/IV).

Journal of the American Chemical Society, 2019
A flow-metallaelectro-catalyzed C-H activation was realized in terms of robust rhodaelectro-catalyzed alkyne annulations. To this end, a modular electro-flow-cell with a porous graphite felt anode was designed to ensure efficient turnover.
Weidong Kong, Lars H. Finger, Antonis M. Messinis, Rositha Kuniyil, João C. A. Oliveira, L. Ackermann   +5 more
semanticscholar   +1 more source